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临床试验/CTRI/2024/09/073969
CTRI/2024/09/073969尚未招募不适用

Randomized Comparative Clinical Evaluation Of Brahmi Taila Nasya And Yoga Module in Chittodvega (Generalized Anxiety Disorder)

Uttarakhand Ayurved University1 个研究点 分布在 1 个国家目标入组 40 人开始时间: 2024年9月28日最近更新:

试验速览

阶段
不适用
状态
尚未招募
发起方
入组人数
40
试验地点
1
主要终点
complete remission-100% relief

研究概览

简要总结

Generalized anxiety disorder (GAD) is a mental health disorder that produces fear, worry and a constant feeling of being overwhelmed. It is characterized by excessive, persistent and unrealistic worry about everyday things. A wide range of psychiatric conditions have been described in Ayurveda. Ayurveda follows psychosomatic approach of health. According to Ayurveda psychic factors are involved in almost all the disease processes along with physical disturbance as both are interdependent. Mind is one of the substratums of diseases and having its own Doshas (Rajasa and Tamasa). Many psychological conditions caused by these Doshas like-Kama (passion), Krodha(anger), Lobha (greed), Moha (confusion), Irshya (envy), Mana (conceit), Mada (arrogance), Chittodvega (anxiety), Bhaya (fear), Harsha (exhilaration) etc. Chittodvega is a Manas Vikara mentioned by Charaka which is considered as a perfect word for highlighting the status of anxiety, Generalized Anxiety Disorder. Chittodvega can exists as a separate disease or can be an etiological factor for other psychic and psychosomatic diseases.Being an alarming disease, it requires effective management. In recent years several synthetic drugs have been introduced for the treatment of anxiety disorders. Though these drugs have better results but one cannot avoid major side effects such as drug dependence, drug resistance, sedation etc. Nasya Karma is the main therapeutic measure of Urdhva Jatrugata Roga. Chittodvega is a Mansik Vikara. Mana is said to be located between Shirah and Talu. All organs, which are above the clavicle, are considered as Urdhvanga e.g., Nasa ,Mukha, Netra and Shirah, without Nasya Karma it is not possible to eliminate the vitiated Doshas, which are situated in the Shirah or Nasa etc.Hence Nasya therapy would have significant role in the treatment of the *Chittodvega.*Yoga reduces stress and anxiety by improving autonomic functions via triggering neurohormonal mechanisms that suppress sympathetic activity through downregulation of the hypothalamic–pituitary–adrenal (HPA) axis. Hence Nasya and Yoga moduleare selected for the present study.

研究设计

研究类型
Interventional
分配方式
Randomized
盲法
None

入排标准

年龄范围
20.00 Year(s) 至 50.00 Year(s)(—)

入选标准

  • Patient fulfilling DSM 5 ,diagnostic criteria for GAD Age group between 20-50 years Gender-Irrespective of gender Patient fit for Nasya and Yoga Willing to give written consent.

排除标准

  • Patient presenting with major illness and psychotic disorders Uncontrolled cases of hypertension Uncontrolled cases of type 1 and type 2 diabetes mellitus Severe cardiac diseases like MI,CAD,IHD Pregnant women Not willing to give written consent.

结局指标

主要结局

complete remission-100% relief

时间窗: At Baseline, 4weeks

Markedly improvement-76-99% relief

时间窗: At Baseline, 4weeks

Moderately improvement-51%-75% relief

时间窗: At Baseline, 4weeks

Mild improvement-26-50% relief

时间窗: At Baseline, 4weeks

次要结局

  • Assessment of sign and symptoms(31 days)

研究者

发起方
Uttarakhand Ayurved University
申办方类型
Government medical college
责任方
Principal Investigator
主要研究者

Dr Krishna Kumar Sharma

Uttarakhand Ayurved University,Rishikul Campus,Haridwar

研究点 (1)

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