Disturbed Blood Flow Induces Endothelial Dysfunction in Severe Chronic Obstructive Pulmonary Disease
Not Applicable
Completed
- Conditions
- Chronic Obstructive Pulmonary Disease
- Registration Number
- NCT03004352
- Lead Sponsor
- University of Split, School of Medicine
- Brief Summary
The aim of the study is to determine if increased retrograde shear would further deteriorate the already impaired vascular function in severe COPD patients.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 27
Inclusion Criteria
- COPD
- chronic hypoxemia
Exclusion Criteria
- an acute exacerbation, active respiratory infection or infection of other localisation 6 weeks prior to the visit
- relevant coexisting lung disease such as interstitial lung disease, cancer, renal failure, thromboembolic disease or major cardiovascular event during the previous year
- informed consent not provided or inability to comply with the study protocol
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Change from Baseline Brachial Artery Diameter at 10, 20 and 25 minutes 0,10, 20 and 25 minutes Change from Baseline Microparticle Count at 20 minutes 0 and 20 minutes
- Secondary Outcome Measures
Name Time Method