ANCA-associated Vasculitis and the Metabolic Syndrom
Completed
- Conditions
- metabool syndroomANCA-associated vasculitis (inflammation of the vessel wall caused by the own immune system) and Metabolic syndrome (combination of risk factors that can lead to diseases that involve the heart or blood vessels)1000381610047066
- Registration Number
- NL-OMON34587
- Lead Sponsor
- Medisch Universitair Ziekenhuis Maastricht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 200
Inclusion Criteria
Patients:
- Age: > 18 years
- Diagnosis: ANCA-associated vasculitis according to the classification criteria of Watts et al.
- Known with the disease for more than 1 year.;Healthy controles:
- Partner of included patient.
Exclusion Criteria
Patients:
- Patients do not fulfil the classification criteria of Watts et al.
- Under aged and legally incapable.
- Immunosuppressive medication: > 15 mg prednison;Healthy controles:
- Under aged and legally incapable
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Primary study parameter:<br /><br><br /><br>Is the prevalence of the metabolic syndrome (NCEP-criteria) increased within<br /><br>ANCA-associated patients compared to healthy controls?</p><br>
- Secondary Outcome Measures
Name Time Method <p>Secundary study parameters:<br /><br><br /><br>- Do relapses occur more frequently within ANCA-associated vasculitis patients<br /><br>who meet the criteria for the metabolic syndrome compared to ANCA-associated<br /><br>vasculitis patients without the metabolic syndrome?<br /><br>- Are the ANCA levels persistently higher within ANCA-associated vasculitis<br /><br>patients who meet the criteria for the metabolic syndrome?<br /><br>- Is the C-reactive protein (CRP) persistently higher within ANCA-associated<br /><br>vasculitis patients who meet the criteria for the metabolic syndrome?<br /><br>- Does proteinuria occur more often within ANCA-associated vasculitis patients<br /><br>who meet the criteria for the metabolic syndrome?</p><br>