B-catenin in Cutaneous Squamous Cell Carcinoma and Its Mimickers
- Conditions
- Cutaneous Squamous Cell Carcinoma
- Interventions
- Biological: Immunohistochemical staining
- Registration Number
- NCT06536946
- Lead Sponsor
- Sohag University
- Brief Summary
Examine the role of B-catenin in differentiation of cutaneous squamous cell carcinoma from other lesions that may be similar to it
- Detailed Description
Skin cancer is one of the most common form of cancer worldwide. Cutaneous squamous cell carcinoma is one of most common skin tumers that caused by many factors as ultra violet ,ionizing radiation and others . It was an advanced spectrum ranging from actinic keratosis to invasive and metastatic squmous cell carcinoma. Correct identification of cutaneous squamous cell carcinoma is a challenge as it has both clinically and histopathologically mimickers.
So the aim of this study is to identify the expression of B-catenin in cutaneous Squamous cell carcinoma and its mimickers.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 50
- tissue blocks with sufficient materials Cases with sufficient data
- tissue blocks with insufficient and necrotic materials. Casas with insufficient data
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Participants Immunohistochemical staining 50 formalin fixed parrafin embedded tissue blocks of cutaneous squamous cell carcinoma and its mimickers , from each block 2 tissue section; one tissue section stained by Hematoxilin and Eoisin and other tissue section will be stained immunohistochemically by anti human B-catenin
- Primary Outcome Measures
Name Time Method Detection of B-catenin expression in cutanous squamous cell carcinoma and its mimickers 6 month Detection of expression of B-catenin in cutaneous squamous cell carcinoma and its mimickers by immunohistochemical procedures using antihuman B-catenin monoclonal antibodies
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Sohag University hospital
🇪🇬Sohag, Egypt