Remote ischaemic postconditioning in the clinical setting

Not Applicable

Completed

Conditions: Topic: Cardiovascular, Neurological
Subtopic: Cardiovascular (all Subtopics), Neurological (all Subtopics)
Disease: Cardiovascular, Nervous system disorders
Circulatory System
Myocardial ischaemia-reperfusion injury

Registration Number: ISRCTN78348355

Lead Sponsor: niversity College London (UCL) (UK)

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: All

Target Recruitment: 500

Inclusion Criteria

1. Patients undergoing percutanous coronary interventions in the elective and emergecy setting and patients undergoing thrombolysis for acute myocardial infarction
2. Aged greater than 18 years and less than 85 years
3. Male and female patients

Exclusion Criteria

1. Aged less than 18 years and greater than 85 years
2. Patients with severe renal impairment (estimated glomerular filtration rate [EGFR] less than 45 ml/min/1.73m2)
3. Patients with severe hepatic impairment
4. Patients with cardiac arrest in the previous 6 weeks

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Myocardial injury, measured by cTnT and CK-MB release over 24 hours after PCI.

Secondary Outcome Measures

Name	Time	Method
1. All-cause mortality, recurrence of symptoms, heart failure and hospitalisation at 1 year after primary percutaneous coronary intervention (PCI)<br>2. Major adverse cardiovascular events (MACE) at 1 year<br>3. Myocardial infarct size, 3 months after primary PCI as measured by cardiac magnetic resonance imaging (MRI)<br>4. Myocardial infarct size and myocardial salvage ratio (infarct size/area at risk) as measured by cardiac MRI