Progression of brain changes in glaucoma

• Conditions: Glaucoma; POAG; 10018307

• Registration Number: NL-OMON44235
• Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 84

Inclusion Criteria

- To have participated in one of the relevant past cross-sectional studies conducted in our lab.
- Signed informed consent.

Exclusion Criteria

For all subjects:
- Development of ophthalmological or neurological disorders which affect the retina, optic nerve or the brain since the last study
- Refusal to be informed in the event of discovering a brain abnormality in the brain scans
- Use of recreational drugs or medications which may influence neurodegenerative progression
- General contraindications of MRI (including MR-incompatible implants and tattoos, and claustrophobia)
Only for controls:
- Visual acuity lower than 0.8

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>For T1-weighted MRI scan: GM volume, WM volume, cortical thickness, cortical<br /><br>surface area, and mean curvature.<br /><br>For Diffusion-weighted MRI scan: Fractional anisotropy (FA) and mean<br /><br>diffusivity (MD).</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Difference in primary parameters between follow-ups.<br /><br>Time interval between follow-ups.</p><br>