The Association Between Clinical, Laboratory and Ultrasonographic Findings With Development of Maternal and Neonatal Complications in Women With Severe Preeclampsia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 284
- 试验地点
- 1
- 主要终点
- Number of participants developed eclampsia
研究概览
简要总结
pregnant women diagnosed with severe preeclampsia were subjected to • Full history taking including a detailed history of the hypertension state during the current pregnancy (onset, course, current medication, and whether the blood pressure is controlled or not).gravidity , parity mode of delivery any medical disorders, the presence of headache ,blurring of vision and epigastric pain.
- Complete physical examination: general (including BMI & blood pressure measurement) and obstetric examinations.
- Routine obstetric ultrasound and Doppler indices Including umbilical artery Doppler (RI).
- Laboratory investigations :
1. Complete blood count (CBC). 2 albuminuria will be detected by dipstick kits . 3. Liver enzymes & kidney function. 4.PT,PC,INR.
- Pelvic-Abdominal ultrasound to assess the presence of ascites Ultrasound examination will be performed by a consultant obstetrician to detect free fluid in the peritoneal cavity, especially at hepato-renal pouch, sub-splenic area, or para-colic gutters.
The presence of ascites will be further confirmed at the time of delivery.
3-All labours will be attended by an expert neonatologist and the following will be recorded:
- APGAR score at (1 min).
- The further need for neonatal intensive care unit (NICU) admission.
- Perinatal death
详细描述
pregnant women diagnosed with severe preeclampsia were subjected to • Full history taking including a detailed history of the hypertension state during the current pregnancy (onset, course, current medication, and whether the blood pressure is controlled or not).gravidity , parity mode of delivery any medical disorders, the presence of headache ,blurring of vision and epigastric pain.
- Complete physical examination: general (including BMI & blood pressure measurement) and obstetric examinations.
- Routine obstetric ultrasound and Doppler indices Including umbilical artery Doppler (RI).
- Laboratory investigations :
1. Complete blood count (CBC). 2 albuminuria will be detected by dipstick kits . 3. Liver enzymes & kidney function. 4.PT,PC,INR.
- Pelvic-Abdominal ultrasound to assess the presence of ascites Ultrasound examination will be performed by a consultant obstetrician to detect free fluid in the peritoneal cavity, especially at hepato-renal pouch, sub-splenic area, or para-colic gutters.
The presence of ascites will be further confirmed at the time of delivery.
3-All labours will be attended by an expert neonatologist and the following will be recorded:
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Maternal age from 18 to 40 years.
- •Gestational age (28_38) weeks, confirmed by the first day of the last menstrual period or first trimesteric ultrasound
- •All suffering of severe preeclampsia
排除标准
- •known liver disease
- •Maternal medical disorders rather than hypertension.
- •Rupture of membrane.
- •Renal disorder.
- •History of illicit drug use.
- •Fetal congenital anomalies.
- •The maternal administration of respiratory depressants within 2 hours from the delivery of the fetus (e. g., opioid analgesic )
- •Associated inflammatory disease or sepsis.
结局指标
主要结局
Number of participants developed eclampsia
时间窗: 3 days after delivery
convulsions in women with severe preeclampsia
次要结局
未报告次要终点
研究者
Ahmed M Maged, MD
Professor
Cairo University