Frequency of Diagnostic Symptomatic Pulmonary Embolism's in Patients Hospitalized for Clinical Exacerbation of Chronic Obstructive Pulmonary Disease (COPD)
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- University Hospital, Brest
- Enrollment
- 750
- Locations
- 13
- Primary Endpoint
- Frequency of pulmonary embolism in patients hospitalized for a clinical exacerbation of COPD.
Study Overview
Brief Summary
A standardized diagnostic strategy of pulmonary embolism will be applied to eligible patients, incorporating a clinical probability score (revised Geneva score), plasma D-dimer assay and if necessary, a multidetector-row CT angiography thoracic and venous ultrasound of the lower limbs. All the patient with a pulmonary embolism diagnosed or not, will be followed for 3 months.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Diagnostic
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Patients hospitalized for a COPD exacerbation
- •COPD previously diagnosed
Exclusion Criteria
- •Allergy to iodinated contrast
- •Creatinine clearance < 30 mL / min
- •Patient hospitalized for exacerbation of COPD for more than 48 hours
- •Pneumothorax
- •Exams impossible to be performed
- •Pregnancy
- •Life expectancy < 3 months
- •Patients already receiving anticoagulant therapy for another reason (mechanical valve, cardiac arrhythmia).
Arms & Interventions
PEP
No drug and no placebo were used in this study. For all the patients who participated at the study PEP, only following exams must be performed: a clinical probability score (revised Geneva score), plasma D-dimer assay and if necessary, a chest multidetector-row CT angiography and venous ultrasound of the lower limbs
Intervention: PEP (Other)
Outcomes
Primary Outcomes
Frequency of pulmonary embolism in patients hospitalized for a clinical exacerbation of COPD.
Time Frame: 27 months
Secondary Outcomes
- The rate of pulmonary embolism diagnosed during the 3 month follow-up in patients whom pulmonary embolism was initially excluded when they've been included in the study(27 months)