Frequency of Diagnostic Symptomatic Pulmonary Embolism's in Patients Hospitalized for Clinical Exacerbation of Chronic Obstructive Pulmonary Disease (COPD)

Not Applicable

Completed

• Conditions: Chronic Obstructive Pulmonary Disease; Patients Hospitalized for a COPD Exacerbation

• Registration Number: NCT02035293
• Lead Sponsor: University Hospital, Brest

Brief Summary

A standardized diagnostic strategy of pulmonary embolism will be applied to eligible patients, incorporating a clinical probability score (revised Geneva score), plasma D-dimer assay and if necessary, a multidetector-row CT angiography thoracic and venous ultrasound of the lower limbs. All the patient with a pulmonary embolism diagnosed or not, will be followed for 3 months.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2014-01-03
• Study Start: 2014-01-08
• Study First Submitted QC: 2014-01-13
• Study First Posted: 2014-01-14
• Primary Completion: 2017-10-13
• Study Completion: 2017-10-13
• Status Verified: 2017-12
• Last Update Submitted: 2017-12-27
• Last Update Posted: 2017-12-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 750

Inclusion Criteria

• Patients hospitalized for a COPD exacerbation
• COPD previously diagnosed

Exclusion Criteria

• Allergy to iodinated contrast
• Creatinine clearance < 30 mL / min
• Patient hospitalized for exacerbation of COPD for more than 48 hours
• Pneumothorax
• Exams impossible to be performed
• Pregnancy
• Life expectancy < 3 months
• Patients already receiving anticoagulant therapy for another reason (mechanical valve, cardiac arrhythmia).

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Frequency of pulmonary embolism in patients hospitalized for a clinical exacerbation of COPD.	27 months

Secondary Outcome Measures

Name	Time	Method
The rate of pulmonary embolism diagnosed during the 3 month follow-up in patients whom pulmonary embolism was initially excluded when they've been included in the study	27 months

Trial Locations

Locations (7)

CHU; 🇫🇷 Angers, France

CHRU de Brest; 🇫🇷 Brest, France

HIA; 🇫🇷 Brest, France

CHU Clermont-Ferrand; 🇫🇷 Clermont-Ferrand, France

Hôpital Européen Georges Pompidou; 🇫🇷 Paris, France

CH de Cornouaille Quimper; 🇫🇷 Quimper, France

Hôpital Nord; 🇫🇷 St-Etienne, France