Interoception in Anorexia Nervosa

• Conditions: Anorexia Nervosa; EEG; Anorexia; Electrocardiogram
• Interventions: Other: Clinical and experimental session

• Registration Number: NCT04981626
• Lead Sponsor: Fondation Santé des Étudiants de France

Brief Summary

Anorexia nervosa is a serious psychiatric illness whose causes remain poorly understood, and which remains difficult to treat to this day. Many clinical manifestations of this disease can have their origin in abnormalities in the perception of signals coming from inside the body, but this remains to be demonstrated. In recent years, research in healthy subjects has shown how the brain constantly perceives the viscera (heart, lungs, stomach). The examiners will use these new, objective and validated methods to explore how the brain processes information from the viscera (interoception) in anorexic patients. In practice, they will quantify the coupling between the cardiac cycle and involuntary eye movements, as well as between the respiratory cycle and voluntary actions such as pressing a button. Finally, by simultaneously recording the electrical activity of the brain, and that of the stomach, the examiners will measure the coupling between the brain and the stomach. All these measurements, which will be compared between a population of patients and healthy subjects, will make it possible to determine whether anorexic patients have an alteration in the perception of their internal body signals and whether this damage affects several organs.

Detailed Description

Not available

Study Timeline

• Status Verified: 2021-07
• Study First Submitted: 2021-07-20
• Study First Submitted QC: 2021-07-27
• Study First Posted: 2021-07-29
• Study Start: 2022-02-14
• Last Update Submitted: 2022-07-22
• Last Update Posted: 2022-07-26
• Primary Completion: 2022-10
• Study Completion: 2023-04

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 50

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
AN group	Clinical and experimental session	* Females * 16 years ≤ Age ≤ 25 years * Diagnostic of AN according to DSM-5 criteria * No past or current psychotic disorders * No current substance abuse or dependence (excluding tobacco). * No current psychiatric medication
Control	Clinical and experimental session	* Females * Age : matched for the AN group * No present or past eating disorders * No past or current psychotic disorders * No current substance abuse or dependence. * No current psychiatric medication

Primary Outcome Measures

Name	Time	Method
measure brain-stomach interactions using phase-amplitude coupling between the gastric phase and the amplitude of the cortical alpha rhythm.	Experimental session - 10 days maximum after inclusion	Examiners will directly measure brain-stomach interactions using phase-amplitude coupling between the gastric phase and the amplitude of the cortical alpha rhythm.

Trial Locations

Locations (1)

ENS; 🇫🇷 Paris, Ile De France, France