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临床试验/NCT03822663
NCT03822663已完成3 期

The Influence of Caffeine Supplementation on Discipline-Specific Performance and Training Activities in Combat Sports and Speed-Strength Disciplines

Poznan University of Physical Education2 个研究点 分布在 1 个国家目标入组 26 人开始时间: 2017年5月15日最近更新:
适应症

试验速览

阶段
3 期
状态
已完成
发起方
入组人数
26
试验地点
2
主要终点
Changes in discipline-specific exercise capacity after caffeine supplementation and placebo treatment

研究概览

简要总结

The purpose of this study is to verify the effect of acute caffeine (CAF) and placebo (PLA) supplementation on physical capacity and discipline-specific exercise performance in athletes, in a randomised, double-blind, placebo-controlled crossover trial.

详细描述

Caffeine (CAF) is often proposed as an ergogenic agent, especially during high-intensity efforts. CAF supplementation may reduce effort-induced multi-faceted symptoms of fatigue and can improve psychomotor functions (like agility or decision-making processes), which is required during the intermittent high-intensity efforts in combat sports and speed-strength disciplines. Moreover, it is suggested that CAF treatment is associated with increased glycolytic activity during simulated or real training/competition bouts, which results in performance and physical capacity improvement.

However, there are hardly any data on the individual CAF-induced and dose-dependent changes in physical capacity and discipline-specific performance in combat sports and speed-strength disciplines. Therefore, the study aims to examine the effect of acute, different-dose CAF ingestion on physical capacity and discipline-specific performance in combat sports and speed-strength athletes, in a randomized, double-blind, placebo-controlled crossover trial.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Crossover
主要目的
Treatment
盲法
Triple (Participant, Investigator, Outcomes Assessor)

入排标准

年龄范围
18 Years 至 40 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • written consent to participate,
  • a current medical clearance to practice sports,
  • training experience: at least 2 years,
  • minimum of 4 workout sessions (in the discipline covered by the study) a week.

排除标准

  • current injury,
  • any health-related contraindication,
  • declared general feeling of being unwell,
  • unwilling to follow the study protocol.

结局指标

主要结局

Changes in discipline-specific exercise capacity after caffeine supplementation and placebo treatment

时间窗: Baseline and during 1 day of acute CAF and PLA supplementation

Assessment of the discipline-specific exercise capacity tests carried out at baseline, and after CAF and PLA supplementation

Changes in reaction and motor time (Vienna Test System) after caffeine supplementation and placebo treatment

时间窗: Baseline and during 1 day of acute CAF and PLA supplementation

Assessment of the reaction and motor time (Vienna Test System) (ms) before and after discipline-specific exercise tests carried out at baseline, and after CAF and PLA supplementation

Changes in postural stability indices (area 95 percentile, Area95) (posturographic platform AccuGaitTM) after caffeine supplementation and placebo treatment

时间窗: Baseline and during 1 day of acute CAF and PLA supplementation

Assessment of the postural stability indices (area 95 percentile, Area95) (posturographic platform AccuGaitTM) (cm2) before and after discipline-specific exercise tests carried out at baseline, and after CAF and PLA supplementation

Changes in postural stability indices (COP velocity, Vcop) (posturographic platform AccuGaitTM) (after caffeine supplementation and placebo treatment

时间窗: Baseline and during 1 day of acute CAF and PLA supplementation

Assessment of the postural stability indices (COP velocity, Vcop) (posturographic platform AccuGaitTM) (cm/s) before and after discipline-specific exercise tests carried out at baseline, and after CAF and PLA supplementation

Changes in caffeine and paraxanthine concencentrations in serum and saliva before and after caffeine supplementation and placebo treatment

时间窗: Baseline and during 1 day of acute CAF and PLA supplementation

Assessment of the caffeine and paraxanthine concencentrations (μg/mL), and paraxanthine/caffeine ratio in serum and saliva before and after discipline-specific exercise tests carried out at baseline, and after CAF and PLA supplementation. Additionally CYP1A2 enzyme activity was assessed by the determination of the mean time-corrected PRX/CAF RATIO in saliva.

次要结局

  • Changes in sports training / competition activities after discipline-specific exercise tests(Baseline and during 1 day of acute CAF and PLA supplementation)
  • Changes in heart rate during discipline-specific exercise tests(Baseline and during 1 day of acute CAF and PLA supplementation)
  • Analysis of psychological state before and after caffeine supplementation and placebo(Baseline and during 1 day of acute CAF and PLA supplementation)
  • Analysis of macronutrients in diets before and after caffeine supplementation and placebo treatment(Baseline and during 1 day of acute CAF and PLA supplementation)
  • Analysis of body composition (fat-free mass, fat mass)(Baseline and during 1 day of acute CAF and PLA supplementation)
  • Analysis of body composition (total body water)(Baseline and during 1 day of acute CAF and PLA supplementation)
  • Changes in rate of perceived exertion after discipline-specific exercise tests(Baseline and during 1 day of acute CAF and PLA supplementation)
  • Changes in lactate and pyruvate concentrations in capillary blood before and after caffeine supplementation and placebo treatment(Baseline and during 1 day of acute CAF and PLA supplementation)
  • Analysis of gene polymorphisms(Baseline)

研究者

发起方
Poznan University of Physical Education
申办方类型
Other
责任方
Principal Investigator
主要研究者

Krzysztof Durkalec-Michalski

Principal Investigator

Poznan University of Physical Education

研究点 (2)

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