Biokinetic studies on the impact of formulation on resveratrol bioavailability
Not Applicable
- Conditions
- metabolism of resveratrol in healthy volunteers
- Registration Number
- DRKS00004311
- Lead Sponsor
- Max Rubner-Institut
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Male
- Target Recruitment
- 12
Inclusion Criteria
healthy men (18 - 40 Jahre)
BMI 20 – 25 kg/m2
non-smoker
participants, who gave written informed consent
Exclusion Criteria
Subjects with serious diseases related to nutrient absorption, digestion, metabolism and excretion.
Subjects who used nutritional supplements or medication within the last three months which might interact with parameters of interest.
Subjects that might be non-compliant.
Subjects with allergies on the study substance or other ingreedients of the formulation.
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method AUC, Camx, tmax of resveratrol and its metabolites in plasma. Analysis by LC-MS/MS before, 20, 40, 60, 90, 120, 180, 270, 360, 480, 720 min and 24h after intake.
- Secondary Outcome Measures
Name Time Method Resveratrol and metabolite excretion in urine. Analysis by LC-MS/MS of sample periods 0-4h, 4-8h, 8-12h, and 12-24h.