NL-OMON45744撤回不适用
Pharmacokinetics of midazolam in the elderly on the Intensive Care Unit: a pilot study - MIKIEL - pilot
Intensive Care0 个研究点目标入组 10 人开始时间: 待定最近更新:
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 发起方
- 入组人数
- 10
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •Age >70 years ;
- •Admitted to the ICU and institution of invasive mechanical ventilation
- •Intravenously administration of midazolam;
- •Expected midazolam administration for at least 12 hours;
排除标准
- •Use of CYP3A4 inhibitors or inductors at the start of the study;
- •o Strong to very strong CYP3A4 inhibitors: boceprevir, clarithromycin, erythromycin, grapefruit juice, indinavir, itraconazole, ketoconazole, posaconazole, ritonavir, saquinavir, telaprevir, telithromycin and voriconazole.
- •o Strong to very strong CYP3A4 inductors: carbamazepine, dabrafenib, rifampicin and Saint John`s-wort.
- •Patients participating in another study;
- •Prescription of other sedatives (except fentanyl);
- •Patients suffering from cerebral condition, that may influence RASS scores.
研究者
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