An evaluation of potential therapies to inhibit cerebral emboli in dementia

niversity Hospital of South Manchester (UK)0 个研究点目标入组 33 人开始时间: 2007年7月6日最近更新: 2020年7月6日

适应症

试验速览

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•1. Dementia: patients must fulfil DSM IV criteria for dementia (Diagnostic and Statistic Manual of Mental Disorders - fourth edition)
•2. AD: patients must fulfil the National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA) criteria
•3. VAD: patients must fulfil the National Institute for Neurological and Communicative Disorders and Stroke -Association Internationale pour la Recherche et l'Enseignement en Neurosciences (NINCDS-AIREN) criteria

•1. Patients with a Mini-Mental State Examination (MMSE) score of less than 10 and/or severe aphasia (as the study requires considerable co-operation)
•2. Current anticoagulant treatment (may reduce spontaneous emboli)
•3. Current clopidogrel treatment
•4. Current statin treatment
•5. Diagnosed as suffering from Atrial Fibrillation (AF)
•6. Diagnosed with significant liver disease: a liver function test will be carried out if liver disease is clinically indicated in any participants
•7. Diagnosed with active pathological bleeding such as peptic ulcer or intracranial haemorrhage
•8. Any surgery scheduled during study involvement
•9. Baseline coagulation parameters suggest unsuitability for clopidogrel/atorvastatin treatment

发起方

niversity Hospital of South Manchester (UK)