Identification of de Novo Fanconi Anemia Patients Using FANCD2 Western Blots
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Identification of Fanconi anemia patients
研究概览
简要总结
This research study is studying identification of de novo Fanconi anemia in younger patients with newly diagnosed acute myeloid leukemia. Studying samples of tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to Fanconi anemia in patients with acute myeloid leukemia.
详细描述
PRIMARY OBJECTIVES:
I. Identify children with newly diagnosed acute myeloid leukemia (AML) treated on COG-2961 and COG-AAML03P1 who are at high risk of having de novo Fanconi anemia.
II. Procure diagnostic samples from the COG AML Biology Repository and identify Fanconi anemia patients using western blot techniques.
OUTLINE:
Previously collected cryopreserved cells are analyzed via western blot to identify patients with Fanconi anemia.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Retrospective
入排标准
- 年龄范围
- — 至 21 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Treated on COG-2961 or COG-AAML03P1
- •At high risk of having Fanconi anemia, defined as meeting one the following groups of clinical criteria:
- •Group 1: Prolonged neutropenia after induction, severe regimen-related toxicity (mucositis, veno-occlusive disease, end-organ damage)
- •Group 2: Early non-relapse death (induction, consolidation)
- •Group 3: Small-for-weight, secondary malignancies
排除标准
- 未提供
结局指标
主要结局
Identification of Fanconi anemia patients
时间窗: Up to 5 months
Identification of children at high risk of having Fanconi anemia
时间窗: Up to 5 months
次要结局
未报告次要终点