The intervention study of the swallowing exercise in patients with SBMA(spinal and bulbar muscular atrophy)

Not Applicable

• Conditions: spinal and bulbar muscular atrophy (SBMA)

• Registration Number: JPRN-UMIN000010277
• Lead Sponsor: JASMITT clinical trial office, Department of Neurology, Nagoya University Graduate School of Medicine

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2013-04-01
• Study Completion: 2013-06-28
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up complete
• Sex: Male
• Target Recruitment: 10

Inclusion Criteria

Not provided

Exclusion Criteria

1)Patients who have taken LH-RH agonists, an LH-RH antagonists, testosterone drugs, anti-androgen drugs, estrogen drugs or unapproved drugs within 48 weeks before agreement acquisition and patients who have taken 5-alpha-reductase inhibitors within 24 weeks before agreement acquisition. 2)Patient who have undergone operations(eg. orchiectomy), which reduce serum testosterone levels. 3)Patients who have severe complications. 4)Patients who can not do neck flexion in a decubitus. 5)Patients who have undergone operations of the head and neck including cervical spine. 6)Patients who are not appropriate to participate to the trial. 7)Patients who are unable to undergo videofluorography. 8)Patient who are unable to undergo MRI inspection.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
severity score of the laryngeal penetration in videofluorography

Secondary Outcome Measures

Name	Time	Method
1)Pharyngeal and oral barium residue (%) in videofluorography 2)stage transition duration, duration of opening upper esophageal sphincter, laryngeal elevation duration, times of swallowing in videofluorography 3)Dysphagia Function Questionnaire 4)motor functional scales 5)serum examination(serum substance P) 6)measurment of tongue pressure 7)Tongue MRI