The effect of cooling therapy on blood cell death in patients who developed cardiac arrest after a heart attack, whose heartbeat was restored and who received body cooling therapy.

Not Applicable

Recruiting

• Conditions: cardiac arrest; myocardial infarction; Emergency medicine - Resuscitation; Cardiovascular - Other cardiovascular diseases

• Registration Number: ACTRN12621001570875
• Lead Sponsor: harran university medical faculty

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2021-11-18
• Last Update Posted: 22 November 2021

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

The criteria for inclusion were a witnessed cardiac arrest, a presumed cardiac origin of the arrest, an age of 18 to 70 years, an estimated interval of 5 to 15 minutes from the patient's collapse to the first attempt at resuscitation by emergency medical personnel, and an interval of no more than 60 minutes from collapse to restoration of spontaneous circulation.

Exclusion Criteria

Patients were excluded if they met any of the following criteria: esophageal temperature below 30 ° C at admission, coma before cardiac arrest due to administration of drugs that suppress the central nervous system, pregnancy, then response to verbal commands, return of spontaneous circulation, and before randomization, spontaneous Evidence of hypotension (mean arterial pressure less than 60 mm Hg), evidence of hypoxaemia (arterial oxygen saturation less than 85 percent) after return of circulation and more than 30 minutes prior to randomization, after return of spontaneous circulation and more than 15 minutes prior to randomization a fatal illness that occurred prior to arrest, factors unlikely to participate in follow-up, enrollment in another study, or a known pre-existing coagulopathy.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To investigate the effect of Goal-Oriented Temperature Therapy on pyroptosis (Pyroptosis measured as a composite of NLRP3, caspase-1, and IL-1Beta protein levels on a venous blood sample using ELISA) in patients with spontaneous circulation after cardiac arrests caused by acute myocardial infarction.[Venous blood was drawn at the start of the cooling therapy (0 hr), within 24 h of treatment and at the end of treatment (48 h).]

Secondary Outcome Measures

Name	Time	Method
mortality ; by accessing patient medical record[48 hours post-intervention commencement]