Does Nocturnal Continuous Positive Airway Pressure Use Improves Sleep Quality in Chronic Obstructive Pulmonary Disease Patients?
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 发起方
- 主要终点
- sleep quality
研究概览
简要总结
Static hyperinflation is frequent in Chronic obstructive pulmonary disease (COPD) , resulting in increased end expiratory lung volume and positive end expiratory pressure (PEEPi) at the end of a normal expiration.
Static hyperinflation worsens the work of breathing is increases patient's dyspnea.
The application of a continuous positive airway pressure (CPAP) has been shown to improve static hyperinflation and to decrease the work of breathing.
Sleep is deteriorated in COPD patients, and causal factors includes static hyperinflation. The purpose of our study is to assess the effect of nocturnal CPAP on sleep quality and functional respiratory parameters.
详细描述
Chronic obstructive pulmonary disease (COPD) is characterized by an airflow obstruction, inducing a flow limitation. As a consequence, we observe in these patients an increased end expiratory lung volume and a positive end expiratory pressure (PEEPi) at the end of a normal expiration.
Patients are breathing at higher pulmonary volumes: this is the concept of static hyperinflation.
This worsens the breathing pattern because in this situation, the work of breathing is increased such that dyspnea increases.
The application of a continuous positive airway pressure (CPAP) has been shown to improve static hyperinflation and to decrease the work of breathing.
Sleep is deteriorated in COPD patients, and causal factors includes static hyperinflation, cough, depression. Moreover, normal physiological changes occuring during sleep in COPD patients are leading to deterioration of gaseous exchanges. The purpose of our study is to assess the effect of nocturnal CPAP on sleep quality and functional respiratory parameters.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •stable chronic obstructive pulmonary disease patients exhibiting a FEV1<80 %,
排除标准
- •Known sleep apnea syndrome or other sleep disease interfering with sleep quality
- •Body mass index > 30 kg/m2
- •heart failure
- •hypnotics intake
结局指标
主要结局
sleep quality
时间窗: day 1
sleep efficiency, total sleep time, sleep architecture measured by polysomnography
次要结局
- static hyperinflation(day 1)