Vasopressin and Epinephrine Versus Epinephrine Alone in Cardiac Arrest

Phase 4

Completed

• Conditions: Cardiac Arrest

• Registration Number: NCT00127907
• Lead Sponsor: Hospices Civils de Lyon

Brief Summary

Recent studies have suggested that arginine-vasopressin could be more effective in the treatment of cardiac arrests. The last published study did not outline obvious improvements in the prognosis of all cardiac arrests but pointed out a possible increased survival rate when arginine-vasopressin is associated with epinephrine. The aim of this study is to compare the efficacy of two successive injections of epinephrine (1 mg) with two successive injections of epinephrine associated with arginine-vasopressin (40 UI) in out-of-hospital cardiac arrests occurring in adult patients. The primary endpoint is the survival rate at hospital admission. The inclusion period lasts 18 months and 2416 patients are planned to be enrolled.

Detailed Description

Not available

Study Timeline

• Study Start: 2004-05
• Study First Submitted: 2005-08-05
• Study First Submitted QC: 2005-08-05
• Study First Posted: 2005-08-09
• Status Verified: 2007-10
• Last Update Submitted: 2007-10-16
• Last Update Posted: 2007-10-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 2416

Inclusion Criteria

• Out-of-hospital medical cardiac arrest in adult patients.

Exclusion Criteria

• Traumatic cardiac arrest
• Pregnancy
• Patients younger than 18 years old or older than 85 years old

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Survival at hospital admission

Secondary Outcome Measures

Name	Time	Method
ROSC (Return of spontaneous circulation) Survival at : H24, Day 28, hospital discharge and one year Neurological status at H24 and hospital discharge.

Trial Locations

Locations (1)

Centre Hospitalier Lyon Sud; 🇫🇷 Pierre Bénite, France