Comparison of Epinephrine Associated With Vasopressin vs Epinephrine Alone in the Treatment of Out-of-hospital Cardiac Arrests
Trial Snapshot
- Phase
- Phase 4
- Status
- Completed
- Sponsor
- Hospices Civils de Lyon
- Enrollment
- 2,416
- Locations
- 2
- Primary Endpoint
- Survival at hospital admission
Study Overview
Brief Summary
Recent studies have suggested that arginine-vasopressin could be more effective in the treatment of cardiac arrests. The last published study did not outline obvious improvements in the prognosis of all cardiac arrests but pointed out a possible increased survival rate when arginine-vasopressin is associated with epinephrine. The aim of this study is to compare the efficacy of two successive injections of epinephrine (1 mg) with two successive injections of epinephrine associated with arginine-vasopressin (40 UI) in out-of-hospital cardiac arrests occurring in adult patients. The primary endpoint is the survival rate at hospital admission. The inclusion period lasts 18 months and 2416 patients are planned to be enrolled.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- Double
Eligibility Criteria
- Ages
- 18 Years to 85 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Out-of-hospital medical cardiac arrest in adult patients.
Exclusion Criteria
- •Traumatic cardiac arrest
- •Pregnancy
- •Patients younger than 18 years old or older than 85 years old
Outcomes
Primary Outcomes
Survival at hospital admission
Secondary Outcomes
- ROSC (Return of spontaneous circulation) Survival at : H24, Day 28, hospital discharge and one year Neurological status at H24 and hospital discharge.