ISRCTN06653773
Completed
未知
A double blind placebo-controlled randomised trial of the addition of mirtazapine for patients with depression in primary care who have not responded to at least 6 weeks of treatment with a selective serotonin reuptake inhibitor or serotonin and noradrenaline reuptake inhibitor.
niversity of Bristol (UK)0 sites400 target enrollmentSeptember 20, 2012
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- niversity of Bristol (UK)
- Enrollment
- 400
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
- 2016 protocol in: http://www.ncbi.nlm.nih.gov/pubmed/26842107 2. 2018 results in: http://www.ncbi.nlm.nih.gov/pubmed/30381374 3. 2018 results in: https://www.ncbi.nlm.nih.gov/pubmed/30468145 4. 2018 qualitative study results in https://www.ncbi.nlm.nih.gov/pubmed/30547766
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\. Aged 18\-75 years
- •2\. Currently taking any of the following SSRI or SNRI antidepressants, for at least 6 weeks at recommended (BNF) doses:
- •2\.1\. Fluoxetine
- •2\.2\. Sertraline
- •2\.3\. Citalopram
- •2\.4\. Escitalopram
- •2\.5\. Fluvoxamine
- •2\.6\. Paroxetine
- •2\.7\. Duloxetine
- •2\.8\. Venlafaxine and who have done so for at least 6 weeks at
Exclusion Criteria
- •GPs will be asked to exclude patients who have bipolar disorder, psychosis or alcohol/substance abuse/dependence or who are pregnant. In addition, we will exclude patients who: are not able to complete the study questionnaires or have a past history of an adverse reaction to mirtazapine.
Outcomes
Primary Outcomes
Not specified
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