Early Outpatient Hysteroscopy Can Prevent Intrauterine Adhesion After Induced Abortion: a Randomized Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 70
- 试验地点
- 2
- 主要终点
- Incidence rate of intrauterine adhesions
研究概览
简要总结
Background: Intrauterine adhesions are a difficult clinical problem for reproductive infertility. The most common cause is uterine cavity surgery and post-abortion (including abortion and spontaneous abortion). After the abortion, the uterine cavity adhesion, when is the key point, the literature is not much ink, early literature has mentioned that after the abortion, the uterus scraping action is scraped in four days and the uterine adhesion will be smaller than one to four weeks. Much more, it seems that the sooner the uterine adhesion factor is excluded, the more it can reduce uterine adhesion, but the uterine curettage itself is a risk factor for uterine adhesion. This early practice, the current clinical application, is not used, Instead, it is a hysteroscopy. Our past clinical observations, as soon as possible after the abortion, outpatient hysteroscopy, can find the tissue factors that may cause adhesion in the uterine cavity as soon as possible, and immediately remove it with an outpatient hysteroscope.
Objective: To verify the early outpatient hysteroscopy and reduce the occurrence of intrauterine adhesion after abortion.
Expected benefits to patients: Abortion is likely to cause intrauterine adhesions, which may further cause the incidence of reproductive infertility, should be involved before the formation of permanent injury, reduce the adhesion of the uterine cavity. Outpatient hysteroscopy is a simple and easy-to-use examination procedure that is painless and does not require anesthesia. Although it is invasive but has few complications, it is expected to reduce the occurrence of intrauterine adhesion after abortion.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 45 Years(Adult)
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •female age 20 to 45 years-old
- •undergo induced abortion
- •desire future fertility
- •agree with the trial and sign the consent form
排除标准
- •previous intrauterine surgery
- •previous intrauterine adhesion
- •previous having over(and/or equal to) 3 times of induced abortion
- •infection condition
结局指标
主要结局
Incidence rate of intrauterine adhesions
时间窗: 6 months later after induced abortion
assess with hysteroscopy
次要结局
- The American Fertility Society (AFS) intrauterine adhesion (IUA) score(6 months later after induced abortion)
- Menstrual cycle condition: Menstrual amount(6 months later after induced abortion)
- Menstrual cycle condition: Menstrual duration(6 months later after induced abortion)
- Menstrual cycle condition: Menstrual symptoms(6 months later after induced abortion)
- Sonography findings:endometrial thickness(6 months later after induced abortion)
- Sonography findings: morphology(6 months later after induced abortion)
- Fertility outcome(2 years later after induced abortion)
