The Predictive Value of Estimated Glomerular Filtration Rate (eGFR) for Adverse Cardiovascular Events in the Hospital in Patients With ST-segment Elevation
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- ST Elevation Myocardial Infarction
- Sponsor
- Dongying Zhang
- Enrollment
- 3
- Primary Endpoint
- major adverse cardiac events
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
Estimated glomerular filtration rate(eGFR) is significantly reduced in patients with ST-segment elevation myocardial infarction (STEMI). The aim of this study is to research that the incidence of adverse cardiovascular events (MACE) in patients with ST-segment elevation myocardial infarction is significantly higher when the glomerular filtration rate below a certain value.
Detailed Description
The investigators retrospectively analyzed the clinical data of 1157 patients with ST-segment elevation myocardial infarction. In-hospital adverse cardiovascular events (MACE) was defined as: cardiac arrest, cardiac rupture, malignant arrhythmia, and cardiac death. All the patients were divided into 3 groups according to the patient's estimated glomerular filtration rate(eGFR) (eGFR≥90ml/min/1.73m2; 90ml/min/1.73m2\>eGFR≥60ml/min/1.73m2; eGFR\<60ml/min /1.73m2). COX regression analysis and K-M survival curves are used to calculate the correlation between eGFR and in-hospital MACE.
Investigators
Dongying Zhang
Professor
Chongqing Medical University
Eligibility Criteria
Inclusion Criteria
- •1.Patients with STEMI 2.Patients from whom informed consent has been properly obtained in writing prior to start of the trial
Exclusion Criteria
- •1.Patients with previous myocardial infarction, congenital heart disease 2.Patients with liver disease, and renal failure 3.Patients with immunologic disease, malignant tumors, pregnancy, infection caused by various pathogens, chronic inflammatory disease, trauma.
Outcomes
Primary Outcomes
major adverse cardiac events
Time Frame: The median time of 7 days
Relationship between reduced eGFR and in-hospital MACE