The effects of reducing worry in patients with persecutory delusions: finding out if worries can be reduced by brief cognitive therapy

Not Applicable

Completed

• Conditions: Persecutory delusions in the context of schizophrenia or related diagnosis; Mental and Behavioural Disorders; Schizophrenia or related diagnosis

• Registration Number: ISRCTN23197625
• Lead Sponsor: The Efficacy and Mechanism Evaluation Programme (MRC/NIHR) (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2011-04-20
• Last Update Posted: 15 January 2018

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

1. A current persecutory delusion as defined by Freeman and Garety (2000); scoring at least 3 on the conviction scale of the PSYRATS (Haddock et al, 1999)
2. That the delusion has persisted for at least one month
3. A clinical diagnosis of schizophrenia, schizoaffective disorder or delusional disorder (i.e. diagnosis of non-affective psychosis (F2) in the International Classification of Diseases and Diagnostic and Statistical Manual IV)
4. A clinically significant level of worry, as indicated by scores above 44 on the Penn State Worry Questionnaire (see Startup and Erickson, 2006)
5. Aged between 18 and 65
6. Where major changes in medication are being made, entry to the study would not occur until at least a month after stabilisation of dosage

Exclusion Criteria

1. A primary diagnosis of alcohol or substance dependency
2. Organic syndrome or learning disability
3. A command of spoken English inadequate for engaging in therapy
4. Currently having individual cognitive behavioural therapy (CBT) (though previous CBT experience is not an exclusion)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. Penn State Worry Questionnaire (PSWQ; Meyer et al, 1990)<br>2. Psychotic Symptoms Rating Scale - Delusions (PSYRATS; Haddock et al, 1999)

Secondary Outcome Measures

Name	Time	Method
1. Paranoid Thoughts Scale (Green et al, 2008)<br>2. Positive and Negative Symptom Scale (PANSS; Kay, 1991).<br>3. EQ-5D (Brooks et al, 2003)