Sustained Attention as Mediator in Mindfulness-Based Cognitive Therapy for Depressio

Not Applicable

• Conditions: F33; Recurrent depressive disorder

• Registration Number: DRKS00006014
• Lead Sponsor: niversität Tübingen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2014-12-19
• Results First Posted: 2018-06-28
• Study Completion: 2019-03-31
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

(a) age between 18 and 65 years, right-handedness, normal hearing ability;
(b) history of recurrent major depression with three or more previous episodes
(c) commitment to homework compliance and to not initiating any changes in medication (starting, suspending, changing dosage) unless a relapse made it necessary.

Exclusion Criteria

(a) current major depressive episode, or presence of dysthymic disorder;
(b) presence of substance abuse, eating disorder, or obsessive-compulsive disorder;
(c) presence or history of one or more of the following: bipolar disorder, borderline personality disorder, schizophrenia or schizoaffective disorder, epilepsy or other neurological disorder, organic mental disorder, pervasive developmental delay;
(d) significant experience with any kind of practice including mindfulness and/or concentration as important element (e.g. meditation, meditative prayer, autogenic training, meditative yoga, etc.).

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Patient's electroencephalogram (EEG) is measured during two meditation tasks at 3 time points: pre-therapy, post-therapy, and at follow-up, 1 year after the end of therapy. Event-related brain potentials (ERP) are obtained from the EEG, especially the contingent negative variation (CNV), a component elicited by a simple stimulus and reflecting the allocation of attentional resources during meditation. The quality of mindfulness and sustained attention during the two meditation tasks is assessed also by the Toronto Mindfulness Scale (TMS), a self-report measure administered immediately after each task at the same 3 time points as the CNV.

Secondary Outcome Measures

Name	Time	Method
Presence and severity of depressive symptoms is monitored weekly by the Center for Epidemiologic Studies Depression Scale (CES-D) administered via internet, starting with the first week of therapy and ending 1 year after the end of therapy (i.e. 60 measuring points: 8 during therapy, 52 during follow-up). Relapse/recurrence of Major Depression during the 1-year follow-up period is assessed retrospectively by the Longitudinal Interval Follow-up Evaluation (LIFE). <br>