Contrast Induced Acute Kidney in Patients With Acute Stroke

• Conditions: Stroke, Acute
• Interventions: Drug: Radiopaque Media

• Registration Number: NCT03132558
• Lead Sponsor: Nanjing Medical University

Brief Summary

Computed tomographic angiography (CTA) is recommended for identifying eligible patient with acute ischemic stroke (AIS) to receieve endovascular treatment. We are going to conduct this prospective corhot study to observe if sequential use contrast in CTA examination and in endovascular treatment will cause acute kidney injury.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-09
• Study First Submitted: 2017-04-25
• Study First Submitted QC: 2017-04-25
• Study First Posted: 2017-04-28
• Primary Completion: 2017-09
• Status Verified: 2017-11
• Last Update Submitted: 2017-11-04
• Last Update Posted: 2017-11-07
• Study Completion: 2017-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• All patients who are suspected with AIS.
• Non-contrast head CT excludes intracranial hemorrhage.

Exclusion Criteria

• Lacking of pre-CTA Creatinine
• Lacking of post-angiography Creatinine with 24-48 hours

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
CTA+DSA	Radiopaque Media	Patients with AIS receieved cerebral CTA, followed by endovascular treatment with the guidence of digital substration angiography (DSA).
CTA	Radiopaque Media	Patients with AIS only receieved cerebral CTA exam.

Primary Outcome Measures

Name	Time	Method
Creatinine	within 24h to 48h	Contrast-induced acute kidney injury was defined as a relative increase of 25% or an absolute increase of 0.3 mg/dL (28.2mol/L) in the serum creatinine level at 48 hours following angiography

Trial Locations

Locations (1)

The First Affiliated Hospital of Nanjing Medical University; 🇨🇳 Nanjing, Jiangsu, China