Effect of sodium glucose cotransporter 2 inhibitors on diabetic macular edema in patient with type 2 diabetes mellitus-a prospective randomnized control trial.

This study is randomnized, double blind, parallel group, placebo controlled trial to analyse the effect of Sodium Glucose Co-Transporter 2 inhibitor (Dapagliflozin). After a detailed informed consent, patients blood sugar will be stabilised for 6 weeks with either oral hypoglycemic agents or insulin or both.At baseline, fundus assessment will be done which would include best corrected visual acuity, slit lamp examination ,IOP measurement, optical coherence tomography and fundus fluorescien angiography.blood pressure assessment will be done.sample will be send for fasting and post prandial blood sugar, HbA1c, serum lipid profile and Serum creatinine. Fundus assesment with coherence tomography and flourecein angiograpy will be repeated at 6 weeks.Patient will be randomly assigned using simple randomisation(lottery method) to one of the following groups.One group will be given Tab Dapagliflozin 10 mg once daily x 3 months ,second group will be given Tab placebo once daily x 3 months and third group will be given Tab Torsemide 20 mg  once daily x 3 months. Final follow up will be done at 4&1/2 months from baseline which would include repeating the same investigations done at baseline to compare with the baseline reports.