Curcumin Supplementation and Patients With Type 2 Diabetes

Not Applicable

Completed

• Conditions: Non Insulin Dependent Diabetes
• Interventions: Dietary Supplement: Curcumin; Dietary Supplement: Placebo

• Registration Number: NCT02529982
• Lead Sponsor: National Nutrition and Food Technology Institute

Brief Summary

Diabetes mellitus is the most common endocrine disorder, causes many complications such as micro- and macro-vascular diseases. Various kinds of antidiabetic drugs have been developed, but most of them have side effects. Recently, the use of natural plant products has gained more attention among scientists in order to prevent diabetic vascular complications. Curcumin is a natural yellow product derived from the turmeric rhizome which has shown to be non-toxic and exhibits various bio¬logical activities such as anti-oxidant, anti-inflammatory, anti-carcinogenic, and anti-diabetic effects. Curcumin is effective in reducing glycemic index and hyperlipidemia in rodent models and is relatively inexpensive and safe. Most of the studies conducted on animal model, and just a few of them are on human model. The present study was planned to evaluate the effects of curcumin supplementation The effect of curcumin supplementation on anthropometric indices, insulin resistance and oxidative stress in patients with type 2 diabetes

Detailed Description

Not available

Study Timeline

• Study Start: 2015-07
• Study First Submitted: 2015-08-19
• Study First Submitted QC: 2015-08-19
• Study First Posted: 2015-08-20
• Primary Completion: 2016-01
• Study Completion: 2016-04
• Status Verified: 2019-02
• Last Update Submitted: 2019-02-24
• Last Update Posted: 2019-02-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 44

Inclusion Criteria

• a) Tendency to participate b) Age range of 40-65 c) Suffering from diabetes type 2 ( between 1 to 10 yeares) d) BMI 18/5-30 e) Patients with diabetes who administer oral hypoglycemic agents and do not use

Exclusion Criteria

• a) patients with liver diseases b) patients with kidney diseases c) patients with inflammatory diseases d) patients with liver diseases e) Administering herbal agents f) Administering multivitamins and minerals in past 3 months

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
intervention	Curcumin	500 mg curcumin capsule
control	Placebo	placebo

Primary Outcome Measures

Name	Time	Method
Insulin	10 week
HbA1c	10 week
fasting blood sugar	10 weeks
Homeostatic Model Assessment of Insulin Resistance	10 week
Change in pancreatic B-cell function	10 week

Secondary Outcome Measures

Name	Time	Method
total capacity antioxidant	10 weeks
Malondialdehyde	10 week
Body mass index	10 week
Waist circumference	10 week

Trial Locations

Locations (1)

NNFTRI clinic; 🇮🇷 Tehran, Iran, Islamic Republic of