Treatment of Epilepsy in Children and Adults in the Emergency Medical Services of the City of Zurich, Switzerland - Midazolam Versus Diazepam - A Retrospective Analysis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 584
- 主要终点
- Which drug (Midazolam versus Diazepam) better stops epileptic seizures in the pre-clinical setting
研究概览
简要总结
Retrospective data analysis, all emergency medical services of the city of Zurich interventions due to epileptic convulsions during June 2013 and December 2014 have been analyzed regarding the type of drug used, its application mode and the application mode based success. Furthermore, children versus adults were compared. Continuous variables were summarized as mean ± standard deviation (SD) and also presented as median [minimum; maximum]. Groups were compared using the independent samples t-test. P-values < 0.05 are considered significant.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- — 至 99 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •emergency calls for epileptic seizures received by the emergency medical system of Zurich,Switzerland,
- •the use of midazolam or diazepam or no drug used.
排除标准
- •the use of any other first line drug to stop seizures than the two mentioned above e.g. thiopental
结局指标
主要结局
Which drug (Midazolam versus Diazepam) better stops epileptic seizures in the pre-clinical setting
时间窗: follow up up to 1 year
In this retrospective trial, all Emergency Medical Services of the city of Zurich interventions due to epileptic seizures during June 2013 and December 2014 are analyzed regarding the two drugs (Midazolam or Diazepam) used, its application mode (intravenous, nasal, intramuscular, rectal) and the application mode based success. Data will be collected regarding these aspects in order to determine if one drug is better than the other one, and which application mode is the most efficient. Furthermore, children versus adults are compared. Continuous variables are summarized as mean ± standard deviation (SD) and also presented as median \[minimum; maximum\]. Groups are compared using the independent samples t-test. P-values \< 0.05 are considered significant.
次要结局
- Does the way of application of the drugs (Midazolam versus Diazepam) used in pre-clinical epileptic seizures influence the outcome(follow up up to 1 year)
研究者
Theusinger Oliver M.
Principal Investigator
Balgrist University Hospital