Hereditary Haemorrhagic Telangiectasia Flight Safety Study

Completed

• Conditions: Hereditary Haemorrhagic Telangiectasia
• Interventions: Other: Aeroplane flight in the past- no active intervention for study; Other: Questionnaire

• Registration Number: NCT01590121
• Lead Sponsor: Imperial College London

Brief Summary

Hereditary Haemorrhagic Telangiectasia (HHT) is a condition in which sufferers have abnormal blood vessels which makes them more likely to bleed than other people, particularly in the lungs, which results in low blood oxygen levels. Flying may make this worse and cause problems. The investigators want to know if there are an increased number of problems on flights compared to on land.

The investigators currently do not have any evidence based guidelines on air travel to best advice people who suffer with HHT. The investigators would therefore like to ask individuals who have HHT about their experience on a flight, using a postal questionnaire.

Detailed Description

Individuals with Hereditary Haemorrhagic Telangiectasia (HHT) previously reviewed at HHTIC London will be sent an invitation to participate in a short questionnaire study.

Quantitative variables from the questionnaires for statistical analysis will be the number of individuals responding (and number of questionnaires sent out); number of flights taken and number of complications, subgrouped by type, and flight duration in hours. Complication rates will be expressed as proportion of person flight hours.

The quantitative data from the questionnaire will then be compared with quantitative data from patients' medical records using non parametric methods such as Mann Whitney for univariate analyses.

Study Timeline

• Study Start: 2010-01
• Primary Completion: 2011-10
• Study Completion: 2011-10
• Study First Submitted: 2012-04-30
• Study First Submitted QC: 2012-05-01
• Study First Posted: 2012-05-02
• Results First Submitted: 2023-09-25
• Status Verified: 2024-09
• Results First Submitted QC: 2024-09-02
• Last Update Submitted: 2024-09-02
• Results First Posted: 2024-11-11
• Last Update Posted: 2024-11-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 156

Inclusion Criteria

HHT

Exclusion Criteria

Unable to provide informed consent

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Pateints with hereditary haemorrhagic telangiectasia	Questionnaire	-
Pateints with hereditary haemorrhagic telangiectasia	Aeroplane flight in the past- no active intervention for study	-

Primary Outcome Measures

Name	Time	Method
HHT Patients Who by the Questionnaire Did or Did Not Self Report a Medical Complication During Flight	Patient were asked to report all flights taken up until questionnaire completion aged 18-90 (mean 55)ys. 145 HHT-affected respondents had flown for 18,943 hours over 3,950 flights.	Of all patients who were sent the questionnaire, this comparison was limited to those who had taken a flight, either long haul or short haul.; Participants were compared as to whether they did or did not suffer a flight complication.

Trial Locations

Locations (1)

HammersmithHospital, Imperial College Healthcare NHS Trust; 🇬🇧 London, United Kingdom