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临床试验/NCT03785314
NCT03785314已完成不适用

Effect of Different Posture on Optic Nerve Sheath Diameter During Thoracic Epidural Catheterization

Keimyung University Dongsan Medical Center2 个研究点 分布在 1 个国家目标入组 44 人开始时间: 2019年1月2日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
44
试验地点
2
主要终点
optic nerve sheath diameter change among 4 time period

研究概览

简要总结

Intracranial pressure is measured indirectly using optic nerve sheath diameter with ultrasound. It is reported that epidural pressure varies according to different posture ( lateral decubitus vs. sitting position).

This study is designed to measure the optic nerve sheath diameter in lateral decubitus and sitting position, respectively.

详细描述

According to previous study, injection of different volume of local anesthetics (1.0 ml/kg vs. 1.5 ml/kg) during caudal anesthesia, high volume of local anesthetics resulted in significant increase of intracranial pressure (ICP). Increase of ICP can reduce regional cerebral flow and oxygen saturation causing the safety of patients. In addition, increase of ICP can result in headache, syncope, and transient loss of visual acuity. Although it is very invasive method, ICP can be measured directly at the brain parenchyme. Among methods to measure the ICP indirectly, measurement of optic nerve sheath diameter using ultrasound is known to reflect the degree of ICP. It is reported that optic nerve sheath diameter increases when higher volume of medication is injected during epidural anesthesia. Previous reports showed that epidural pressure varies according to different posture. When epidural pressure was measured in patients of spinal stenosis, lumbar flexion showed lower epidural pressure than epidural pressure of lumbar extension. In addition, when epidural pressure was measured in the sitting position, it showed lower pressure than pressure of lateral decubitus.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
Double (Participant, Outcomes Assessor)

入排标准

年龄范围
20 Years 至 80 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • lung cancer
  • liver cancer
  • stomach cancer
  • pancreas cancer

排除标准

  • coagulopathy
  • infection
  • previous spine fusion at thoracic level
  • previous brain surgery

结局指标

主要结局

optic nerve sheath diameter change among 4 time period

时间窗: Baseline, 10 minutes, 20 minutes, 40 minutes after the completion of the intervention

optic nerve sheath diameter change among 4 time period using ultrasound

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Ji Hee Hong

Professor

Keimyung University Dongsan Medical Center

研究点 (2)

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