Egyptian Arthroplasty Surgeons' Antibiotics Usage Awareness

Completed

• Conditions: Infections Joint Prosthetic

• Registration Number: NCT06451224
• Lead Sponsor: South Valley University

Brief Summary

Total hip arthroplasty (THA) and total knee arthroplasty (TKA) are procedures successfully applied to manage various end-stage chronic hip and knee diseases, such as osteoarthritis, rheumatoid arthritis, and femoral head avascular necrosis, as well as acute conditions, such as the neck of femur fractures, with excellent long-term functional outcomes. One of the devastating complications after such a procedure is periprosthetic joint infection (PJI). Various precautions are proposed to guard against such complications; one is the administration of perioperative antibiotics. However, injudicious or misuse of antibiotics could lead to the emergence of antimicrobial resistance, further complicating this matter. This is why various scientific and research organizations have proposed guidelines and a consensus for proper antibiotic use in perioperative THA and TKA surgery.

Antibiotic prophylaxis during primary THA and TKA can reduce the risk of PJI and surgical site infections. However, there is a lack of consensus on the optimal dosages and duration of prophylaxis, and guidelines vary among institutions. Alternatives such as extended oral antibiotic prophylaxis and different antibiotic regimens are being explored. International research is needed to establish best practices and determine the potential risks of antibiotic prophylaxis during primary THA and TKA. Unfortunately, the investigators are unaware of such guidelines proposed by any Egyptian health authority to guide and control the proper utilization of antibiotics during orthoapedic practice in general and joint replacement surgeries (THA and TKA) in particular.

Detailed Description

This study will be an Online-based questionnaire investigating surgeons' perspectives on antibiotics utilization during primary total hip and knee arthroplasty surgeries and investigate their thoughts about the necessity for developing local guidelines.

Study Timeline

• Study First Submitted: 2024-05-23
• Study First Submitted QC: 2024-06-09
• Study First Posted: 2024-06-11
• Study Start: 2024-06-15
• Primary Completion: 2024-08-30
• Study Completion: 2024-09-30
• Status Verified: 2024-10
• Last Update Submitted: 2024-10-13
• Last Update Posted: 2024-10-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 105

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To determine the type of antibiotics administration during primary total hip and knee arthroplasty	2 months	The type of antibiotics will be determined as follows: the name of the antibiotic (brand or generic), and if single or dual antibiotics are used. These will be presented as numbers and percentages.

Secondary Outcome Measures

Name	Time	Method
To determine the dose of antibiotics administered during primary total hip and knee arthroplasty	2 months	The dose of antibiotics will be determined as grams or milligrams. Furthermore, the number of doses will be reported
To determine the length of antibiotics administration during primary total hip and knee arthroplasty	2 months	the length of antibiotic administration postoperatively will be calculated in days.
To determine the timing of antibiotics administration during primary total hip and knee arthroplasty	2 months	Regarding the timing, preoperative antibiotic administration will be reported in minutes

Trial Locations

Locations (1)

Assuit Faculty of Medicine; 🇪🇬 Assiut, Egypt