AISTCM-Outcome Measurement of Acute Ischemic Stroke With Traditional Chinese Medicine
- Conditions
- Cerebral Infarction
- Interventions
- Drug: Erigeron breviscapus injectionDrug: hua tuo zai zao wan (a herbal medicine pill)Drug: Compound stroke herbal medicine (8 herbal)
- Registration Number
- NCT00351806
- Brief Summary
The purpose of this study is to determine whether Traditional Chinese Medicine (TCM) is able to improve the outcome of acute ischemic stroke and to observe its safety.
- Detailed Description
The purpose of this study is to determine whether Traditional Chinese Medicine (TCM) is able to improve the outcome of acute ischemic stroke and safety.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 500
- Ischemic stroke diagnosis by CT/MRI scan
- Yin pattern of Traditional Chinese Medicine Theory
- 40-85 years old
- Total anterior circulation infarcts (TACI), partial anterior territory cerebral infarction (PACI), lacunar anterior circulation infarcts (LACI) type under Oxfordshire Community Stroke Project (OCSP) standard
- NIHSS >=4;
- Glasgow coma scale (GCS) >=7;
- Modified Rankin Scale less than 2 degrees before onset of this stroke
- Informed consent signed by patient or his/her family
- Hemorrhagic stroke;
- Coma, GCS<=7;
- Cerebral hernia;
- Serious heart, liver, lung, kidney functional failure;
- Gastrointestinal (GI) bleeding;
- Thrombolysis drugs or surgery was administrated to the patient;
- Not cooperative with physician;
- Psychological disorder;
- Already taken part in other clinical drug trial within the past 3 months
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Chinese herbal medicine Erigeron breviscapus injection - Chinese herbal medicine hua tuo zai zao wan (a herbal medicine pill) - Chinese herbal medicine Compound stroke herbal medicine (8 herbal) -
- Primary Outcome Measures
Name Time Method death rate, Barthel Index
- Secondary Outcome Measures
Name Time Method Glasgow Outcome Scale (GOS) Modified Rankin Scale (mRS) National Institute of Health Stroke Scale (NIHSS) Stroke Specific Quality of Life (SSQOL) Scale of Traditional Chinese Medicine (SSTCM)
Trial Locations
- Locations (22)
Foshan Hospital of Traditional Chinese Medicine
🇨🇳Foshan, Guangdong, China
2nd hospital of Zhongshan University
🇨🇳Guangzhou, Guangdong, China
Yueyang Hospital of Shanghai University of Traditional Chinese Medicine
🇨🇳Shanghai, Shanghai, China
zhongshan hospital of Fudan Unversity
🇨🇳Shanghai, Shanghai, China
Ruikang Hospital of Traditional Chinese Medicine
🇨🇳Nan Ning, Guangxi, China
Neurology Center, Guangdong Province Hospital of Tradtional Chinese Medicine
🇨🇳Guangzhou, Guangdong, China
1st Hospital of Guangxi college of Traditional Chinese Medicine
🇨🇳Nanning, Guangxi, China
Taizhou Hospital of Traditional Chinese Medicine
🇨🇳Taizhou, Jiangsu, China
Jinan Hospital of Traditional Chinese Medicine
🇨🇳Jinan, Shandong, China
The Hosptial of Shanxi College of Traditional Chinese Medicine
🇨🇳Xian yang, Shanxi, China
The People's Hospital of Sichuan Province
🇨🇳Chengdu, Sichuan, China
Xinjiang Uygur Autonomous Region Hospital of Traditional Chinese Medicine
🇨🇳Urumqi, Xinjiang, China
Longhua Hospital of Shanghai University of Traditional Chinese Medicine
🇨🇳Shanghai, Shanghai, China
The 2nd Hospital of Wenzhou Medical College
🇨🇳Wenzhou, Zhejiang, China
Huashan Hospital of Fudan Unveristy
🇨🇳Shanghai, Shanghai, China
Zhejiang Province Hospital of Traditional Chinese Medicine
🇨🇳Hangzhou, Zhejiang, China
The 1st Hospital of He'nan College of Traditional Chinese Medicine
🇨🇳Zhengzhou, Henan, China
The teahing hospital of Hubei College of Traditional Chinese Medicine
🇨🇳Wuhan, Hubei, China
Shanghai Hospital of Traditional Chinese Medicine
🇨🇳Shanghai, Shanghai, China
Shuguang Hospital of Shanghai University of Traditional Chinese Medicine
🇨🇳Shanghai, Shanghai, China
Dongzhimen Hospital of Beijing University of Traditional Chinese Medicine
🇨🇳Beijing, Beijing, China
Zhongshan Hospital of Traditional Chinese Medicine
🇨🇳Zhongshan, Guangdong, China