altrexone depot implant in the treatment of co-morbid amphetamine and opioid dependence

Not Applicable

Completed

• Conditions: Amphetamine and opioid dependence (DSM-IV); Mental and Behavioural Disorders; Opioid dependence

• Registration Number: ISRCTN88905555
• Lead Sponsor: ational Institute for Health and Welfare (THL) (Finland)

Brief Summary

2012 results in: https://www.ncbi.nlm.nih.gov/pubmed/22764364 (added 21/08/2019)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2007-10-30
• Study Completion: 2011-02-28
• Last Update Posted: 9 September 2019

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

1. Primary diagnosis of current Amphetamine and Opioid Dependence (Diagnostic and Statistical Manual of Mental Disorders, fourth edition [DSM-IV]), present for at least one year
2. Age between 18 and 50 years
3. Education as high school graduate or above
4. Negative urine toxicology and alcohol breath tests
5. Not currently on psychotropic medication
6. At least one relative willing to participate in treatment, monitor administration of medications, assist in follow-up, and provide outcome data
7. Stable address within St. Petersburg or nearest districts of Leningrad Region
8. Home telephone number at which the patient can be reached
9. Negative pregnancy test and use adequate contraception if of childbearing age
10. Willingness and ability to give informed consent and otherwise participate

Exclusion Criteria

1. Clinically significant cognitive impairment, schizophrenia, paranoid disorder, bipolar disorder, or seizure disorder
2. Advanced neurological, cardiovascular, renal, or hepatic disease
3. Active tuberculosis or current febrile illness
4. Acquired Immune Deficiency Syndrome (AIDS)-defining illness
5. Significant laboratory abnormality such as severe anaemia, unstable diabetes, or liver function tests greater than 3 x above normal
6. Pregnancy
7. Pending legal charges with potential impending incarceration
8. Concurrent participation in another treatment study
9. Concurrent treatment in another substance abuse program

Study & Design

• Study Type: Interventional
• Study Design: Not specified