Fractional Photothermolysis for the Treatment of Burn Scars
试验速览
- 阶段
- 1 期
- 发起方
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- Evidence of improvement in color and texture of burn scars, using digital colorimeter and digital photography.
研究概览
简要总结
The aim of our study is to determine the effect of fractional photothermolysis laser in the treatment of burn scars.
详细描述
One of the main problems in the management of burned patients is the treatment of post-burn scarring. Frequently this scars cover large areas, tend to retract, present pigmentary changes and are disfiguring, producing significant life quality impairment.
Unfortunately, there are very few therapeutic options for treating these scars, which can be secondary to reconstructive surgery or after spontaneous healing. In the last decades most reports in scar treatment have included, pressure garments, chemical peeling, dermabrasion, ablative and non-ablative laser therapy and surgery with varying degrees of success. There is only one report treating burn scars with fractional laser, with good results.
The aim of our study is to determine the effect of of a second-generation erbium-doped 1,550-nm fractional photothermolysis laser (Fraxel SR laser, Reliant Technologies Inc.) in the treatment of burn scars.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 6 Years 至 16 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Burn scars should be located on the anterior thorax or abdomen with at least 4 months of evolution.
- •The scar should be slightly elevated, with erythema and with no signs of keloid formation.
- •Maximum scar dimension: 0.2 - 1% body surface area.
- •Acceptance of informed consent for laser treatment.
排除标准
- •Previous non-surgical treatment (i.e. dermabrasion, laser, peelings, bleaching agent. etc).
- •Previous surgical treatment (i.e. graft)
结局指标
主要结局
Evidence of improvement in color and texture of burn scars, using digital colorimeter and digital photography.
时间窗: 5 months
Adverse effects: pain, erythema, edema, hypopigmentation, hyperpigmentation, hypertrophic scar and keloid formation
时间窗: 5 months
次要结局
- Change in surface area and perimeter of burn scar(5 months)
- Tissue pliability, elevation and flexibility with a digital piedemeter(5 months)
- Change in collagen fiber organization and blood vessel density with a reflectance laser confocal microscope.(5 months)