Variation in Rate of Orthodontic Tooth Movement in Response to Platelet Rich Plasma Therapy

Phase 4

• Conditions: Tooth Movement
• Interventions: Biological: platelet rich plasma

• Registration Number: NCT04016727
• Lead Sponsor: Armed Forces Institute of Dentistry, Pakistan

Brief Summary

PRP from 5 ml blood was prepared and 60 units were injected into the buccal vestibule of patient before initiating canine retraction using NiTi coil spring. Pre and post cervical, incisal and mid distances were measured using Vernier calliper.

Detailed Description

Platelet rich plasma was prepared using patients own blood. The production of PRP began with a 6-mL homologous blood sample that was withdrawn from the donor via venupuncture. One milliliter of the blood sample was set apart to determine the concentration of platelets and leukocytes in whole blood. The remaining 5 mL was mixed with an anticoagulant (3.8%, 1-mL sodium citrate) to prevent clotting. The blood sample was centrifuged at 113 g for 5 minutes to separate the plasma containing the platelets from the red cells. The plasma was drawn off the top and centrifuged for an additional 2 minutes at 3772 g to separate the platelets. Suitable platelet concentrations were achieved by the resuspension of PRP with plasma (high platelet concentration, 5 times the concentration in whole blood).

Study Timeline

• Study Start: 2018-07-02
• Primary Completion: 2019-03-02
• Study First Submitted: 2019-06-28
• Study First Submitted QC: 2019-07-10
• Study First Posted: 2019-07-11
• Status Verified: 2020-01
• Last Update Submitted: 2020-01-20
• Last Update Posted: 2020-01-22
• Study Completion: 2020-02-02

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• patients requiring first premolar extractions

Exclusion Criteria

• patients taking any drugs, steroids, NSAIDs and antibiotics
• patients with any co morbid conditions

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
PRP group	platelet rich plasma	patients in which 60 units of prp was injected

Primary Outcome Measures

Name	Time	Method
canine movement in mili meters	1 month	distance was measured using vernier caliper at mid cervical and incisal region

Trial Locations

Locations (1)

AFID; 🇵🇰 Rawalpindi, Punjab, Pakistan