Effect of Exercise Training on Salivary Immunoglobulin A in Patients With Chronic Obstructive Pulmonary Disease
Not Applicable
Completed
- Conditions
- COPD
- Interventions
- Other: Pulmonary rehabilitation
- Registration Number
- NCT04604717
- Lead Sponsor
- Bayside Health
- Brief Summary
The purpose of this study is to determine whether whole body exercise training alters the immunity in the lungs of people with COPD and reduces the incidence of chest infections over the longer term.
- Detailed Description
Patients will undertake an 8 weeks pulmonary rehabilitation program of exercise and education. Those who decline to take part in pulmonary rehabilitation will have the same outcome measures collected at the same timepoints.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 35
Inclusion Criteria
- Diagnosis of COPD (FEV1/FVC < 70), smoking Hx of minimum of 10 pack years
Exclusion Criteria
- Diagnosis of asthma, bronchiectasis, attendance at pulmonary rehabilitation within last 12 months, exacerbation of COPD within last 4 weeks
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Pulmonary rehabilitation Pulmonary rehabilitation 8 weeks of pulmonary rehabilitation (twice weekly training) Exercise and education sessions accompanied by home exercise program
- Primary Outcome Measures
Name Time Method Change in Salivary Immunoglobulin A levels Change over 8 weeks SIgA
- Secondary Outcome Measures
Name Time Method Change in circulatory inflammatory markers Change over 8 weeks Change in physical activity levels Change over 8 weeks Health status Change over 8 weeks COPD assessment test
Exercise capacity (6MWT) Change over 8 weeks Distance walked in 6 minutes
Number of acute exacerbations 12 months
Trial Locations
- Locations (2)
Austin Health
🇦🇺Melbourne, Victoria, Australia
Alfred Health
🇦🇺Melbourne, Victoria, Australia