Impact of Adductor Canal Block, Compared to Patient Controlled Analgesia, in the Surgical Stress Response of Patients Programmed for Traumatic Anterior Cruciate Ligament Repair
试验速览
- 阶段
- 1 期
- 状态
- 撤回
- 试验地点
- 1
- 主要终点
- Change of Blood Cortisol from baseline to 24 hours
研究概览
简要总结
To evaluate the surgical stress response in anterior cruciate ligament repair with an adductor canal block versus patient controlled endovenous analgesia.
详细描述
Preoperative, 2 hours and 24 hours stress biomarkers will be evaluated in two groups of patients, continous adductor canal block and morphine patient controlled endovenous analgesia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •18-65 years,
- •traumatic Anterior Cruciate Ligament tear, scheduled for elective arthroscopic repair with Semitendinous-Gracillis technique at first time in the morning, with full articular range,
- •no other traumatologic lesions.
排除标准
- •denied consent to participate,
- •chronic steroids user,
- •diabetes type 1 or 2,
- •insulin resistance,
- •concurrent infectious disease,
- •cognitive failure, coagulopathy,
- •allergy to study drugs,
- •surgery scheduled in the afternoon
研究组 & 干预措施
Adductor Canal Block
With mild sedation, a continous bupivacaine 0.1% infusion catheter is placed in the adductor canal. Afterwards, patients are placed under General Anesthesia, and surgery starts. Preoperative, 2 hours and 24 hours stress biomarkers and analgesic quality will be measured.
干预措施: Adductor Canal Block (Procedure)
Patient Controlled Morphine Analgesia
Patients are placed under General Anesthesia, and after surgery, a Morphine patient controlled analgesia delivery system is installed. Preoperative, 2 hours and 24 hours stress biomarkers and analgesic quality will be measured.
干预措施: Morphine Patient Controlled Analgesia (Device)
结局指标
主要结局
Change of Blood Cortisol from baseline to 24 hours
时间窗: 24 hours
Blood Cortisol will be evaluated preoperatively, 2 hours and 24 hours postoperatively.
次要结局
- Change of Glycemia from baseline to 24 hours(24 hours)
- Change of C Reactive Protein from baseline to 24 hours(24 hours)