The Study of Differences in Eosinophil Function and Subsets in Patients With Eosinophilic Pulmonary Diseases

Recruiting

• Conditions: Eosinophil Subtype; Eosinophilic Pulmonary Diseases

• Registration Number: NCT06944418
• Lead Sponsor: Peking Union Medical College Hospital

Brief Summary

The study subjects of this research are patients with eosinophil-associated pulmonary diseases, including eosinophilic granulomatosis with polyangiitis, idiopathic hypereosinophilic syndrome, idiopathic acute eosinophilic pneumonia, idiopathic chronic eosinophilic pneumonia, and primary simple pulmonary eosinophilia. The aim is to detect eosinophil subtypes in peripheral blood based on surface protein expression, to understand the differences in eosinophil subtypes among patients with different diseases, to elucidate the significance of different eosinophil subtypes, and ultimately to provide a theoretical basis for the selection of treatment directions for patients.

Detailed Description

Not available

Study Timeline

• Study Start: 2024-01-01
• Study First Submitted: 2025-03-30
• Status Verified: 2025-04
• Study First Submitted QC: 2025-04-22
• Last Update Submitted: 2025-04-22
• Study First Posted: 2025-04-25
• Last Update Posted: 2025-04-25
• Primary Completion: 2026-01-01
• Study Completion: 2027-01-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

• For Healthy Volunteers: healthy volunteers matching the age and gender of the study subjects
• For EPD: ① Persistent eosinophil count increase>1500 per cubic millimeter for more than 6 months. ② Lack of evidence of a secondary cause of eosinophilia is required. ③ Signs and symptoms of end-organ damage presumed to be secondary to eosinophilia

Exclusion Criteria

• Patients with concurrent definitive pulmonary infections, malignancies, or other parenchymal lung diseases;
• Patients who are unable or unwilling to cooperate with the collection of clinical information (e.g., due to mental disorders, memory impairments, etc.);
• Patients who are unable to provide informed consent.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Proportion of Eosinophil Subtypes in Serum	From January 1, 2024 to January 1, 2027	Proportion of Eosinophil Subtypes in Serum Before and After Treatment in Patients

Trial Locations

Locations (1)

Peking Union Medical College Hospital; 🇨🇳 Beijing, Beijing, China