NL-OMON45136已完成不适用
Breast conserving therapy using Accelerated Partial Breast Irradiation (APBI) in elderly patients: a feasibility study - Breast conserving therapy using APBI in elderly patients
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 509
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •Histological confirmed breast cancer (DCIS and invasive) ductal subtypes
- •T1-2 smaller than 30mm as determined by ultrasound
- •N0 on palpation and ultrasound examination
- •Unicentric, Unifocal disease (radiological), multifocal when limited within 2 cm of the index lesion)
- •Any hormonal receptor status, hormonal therapy allowed following Dutch treatment guidelines
- •Technically eligible for lumpectomy or radiotherapy
- •No contra indications for lumpectomy and sentinal node procedure
- •Written informed consent
- •Willing to fill out the QOL, geriatric- and co morbidity questionaires - if applicable
排除标准
- •Patients not eligible / fit for lumpectomy and sentinal node procedure
- •pT2 (>30mm), pT3 and pT4
- •Positive surgical margins
- •Multi centricity; multifocal (> 2cm from the index lesion)
- •Extensive intraductal carcinoma; lympho-vascular invasion
- •Previous treatment of ipsilateral breast tumor (DCIS or invasive)
- •Paget disease of the nipple
- •Cutaneous involvement
- •Distant metastases; > pN1a
- •Previous radiotherapy on the ipsilateral breast
- •neo adjuvant chemotherapy for current malignancy
- •Collagen diseases (systematic erythematosus lupus, scleroderma, dermatomyositis)
- •Psychiatric diseases or other that prevents signing of informed consent
- •Other neoplasm's in the last 5 year with exception of skin tumors (excl melanoma) and intraepthelial lesions of the cervix uteri
研究者
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