Based on the follicle-granulosa cell metabolic pathway to explore the effects of zaoshi-phlegm-reducing Traditional Chinese medicine on the developmental potential and energy metabolism of phlegm-dampness

Not Applicable

• Conditions: polycystic ovarian syndrome

• Registration Number: ITMCTR2100005340
• Lead Sponsor: Affiliated Hospital of Shandong University of Traditional Chinese Medicine

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 20 February 2023

Recruitment & Eligibility

• Status: Pending
• Sex: Female
• Target Recruitment: Not specified

Inclusion Criteria

Married women aged 35-45; This disease conforms to western medicine diagnosis and Chinese medicine phlegm-dampness syndrome differentiation standard.
Diagnostic criteria of polycystic ovary syndrome:
The Gynecological Endocrinology Group of The Chinese Society of Obstetrics and Gynecology formulated the 2011 Chinese DIAGNOSTIC Criteria for PCOS : amenorrhea, sporadic menstruation or irregular uterine bleeding are the necessary criteria. Suspected PCOS can be diagnosed with at least one of the following: clinical manifestations of hyperandrogen or hyperandrogenemia; Ultrasound suggests polycystic ovaries (at least one ovary has more than 12 follicles 0.2 -- 0.9cm in diameter, or an ovarian volume greater than or equal to 10cm3). Suspected PCOS patients must be excluded from other conditions that may cause ovulation disorders and high androgen levels. Compared with international standards, Chinese PCOS diagnostic criteria emphasize more on the pathological role of ovarian dysfunction and are more suitable for the actual situation of Chinese women.
Syndrome differentiation of phlegm-dampness polycystic ovary syndrome: formulated with reference to the Chinese Medicine Industry standard of the People's Republic of China - Standard of Diagnosis and Efficacy of Chinese Medicine Diseases and the seventh edition of the national unified textbook Gynecology of Chinese Medicine.
Main syndrome: ? long marriage infertility; ? Late menstruation, or gradually to amenorrhea; ? Less menstruation, light red color.
And disease: ? body fat; (2) chest nausea; (3) the amount of sticky belt; ? Loose stool or diarrhea through menstruation.
Tongue pulse: the tongue is pale and white and greasy with moss, and the pulse is slippery and weak.
The above three main syndromes are necessary, and one or two concurrent syndromes can be diagnosed, with tongue pulse as reference.

Exclusion Criteria

Patients with abnormal adrenal, thyroid and pituitary endocrine functions, such as adrenal cortical hyperplasia, adrenal cortical hypofunction, hyperthyroidism, hypothyroidism, pituitary tumor, Sheehan's syndrome, diabetes, etc. Patients with cardiovascular and cerebrovascular diseases, such as hypertension and coronary heart disease; Patients with liver and kidney diseases; Patients with neurological or mental diseases; Patients with blood diseases; Patients with acute genitourinary inflammation; Patients with reproductive system tumors; Organic diseases of reproductive organs; Patients who take birth control pills or other hormone-containing drugs within three months; Physiologic late menstruation and amenorrhea; Patients with poor compliance.

Study & Design

• Study Type: Interventional study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Oocyte mass;