Identifying subgroups within a population of chronic non-specific low back pain sufferers, and investigating the role of the immune system in certain subgroups by considering their relationship to chronic primary pain syndromes

Not Applicable

• Conditions: on-specific low back pain; Musculoskeletal Diseases; Low back pain

• Registration Number: ISRCTN98833037
• Lead Sponsor: niversity of Liverpool

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2021-06-23
• Last Update Posted: 26 July 2021
• Study Completion: 2023-12-01

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

1. 18 years or older
2. Presence of non-specific LBP without the presence of another condition to explain the pain (ie. cancer, primary musculoskeletal conditions, sciatica)
3. Chronic NsLBP defined as pain persisting for >12 weeks, with pain occurring >4 days/week
4. Non-specific LBP as defined topographically and temporally by the Delphi definition
5. Average weekly pain intensity exceeding 6/10 on VAS scoring
6. LBP that causes severe disability, as defined by the Modified Oswestry Low Back Pain Disability Questionnaire (MODI)
7. Pain may radiate down the buttocks or backs of legs but must not radiate below the knees
8. In patients with features of more widespread, non-specific pain, the low-back pain must be the predominant complaint of pain and the pain intensity of these other pains should not exceed 3/10 on VAS scoring

Exclusion Criteria

1. Pregnant or breastfeeding patients
2. Patients with immune deficiency or taking immune modulating drugs
3. Patients with an acute systemic disorder
4. Language other than English as first language

Study & Design

• Study Type: Observational
• Study Design: Not specified