A Randomised Controlled Study to Evaluate the Effect of Perioperative Intravenous Lignocaine versus Ketamine versus Normal Saline on Post Operative Pain after Abdominal Surgeries under General Anaesthesia at SMS Medical College, Jaipur.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 126
- 试验地点
- 1
- 主要终点
- 1.To assess and compare the difference in time to first rescue analgesic administration in first 24 hours postoperatively among the groups.
研究概览
简要总结
This randomized controlled study aimed to evaluate the effectiveness of perioperative intravenous lignocaine and ketamine compared to normal saline in managing postoperative pain following abdominal surgeries under general anaesthesia. Patients were randomly assigned to receive either IV lignocaine, IV ketamine, or normal saline during the perioperative period. Pain intensity was assessed at various postoperative intervals using standardized pain scales, along with measurements of total opioid consumption and time to first rescue analgesia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 99.00 Year(s)（—）
- 性别
- All
入选标准
- •1.Patients scheduled for abdominal surgeries under general anaesthesia.
- •2.Patient willing to give informed written consent.
- •3.American Society of Anaesthesiologist (ASA) physical status I and II.
- •4.Duration of surgery upto 120 minutes.
排除标准
- •1.Patient who is a part of any other study.
- •2.Pregnant or breastfeeding patients.
- •3.Obese 4.Chronic preoperative opioid use or substance abuse and history of chronic pain.
- •5.Allergy or contraindications to use of study medications such as cardiac, renal, hepatic disease, seizure or other neurological disorder.
- •6.Patients requiring postoperative mechanical ventilation.
结局指标
主要结局
1.To assess and compare the difference in time to first rescue analgesic administration in first 24 hours postoperatively among the groups.
时间窗: 1.To assess and compare the difference in time to first rescue analgesic administration in first 24 hours (1hr, 2hrs, 3hrs, 4hrs, 6hrs, 8hrs, 10hrs, 12hrs, 18hrs, 24hrs)postoperatively among the groups.
次要结局
- 1. To assess & compare the difference in mean rescue analgesic consumption in first 24 hours postoperatively among the groups(2.To assess & compare the difference in mean VAS scores in first 24 hours (1hr, 2hrs, 3hrs, 4hrs, 6hrs, 8hrs, 10hrs, 12hrs, 18hrs, 24hrs) postoperatively among the groups.)
研究者
Dr Kanchan Chauhan
Sawai Man Singh Medical College and Hospital