The effect of Milk Thistle extract versus tea on serum iron increase after a meal containing non-haem iron in Hereditary Haemochromatosis: a pilot study

Completed

• Conditions: Hereditary Haemochromatosis (HH); Nutritional, Metabolic, Endocrine

• Registration Number: ISRCTN10982081
• Lead Sponsor: King's College London (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2006-09-12
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

1. Patients will be homozygous for the C282Y mutation of the HFE gene (the genotype associated with type one hereditary haemochromatosis), and have phenotypic haemochromatosis (identified by raised serum iron levels on diagnosis), as this is the particular group of interest which may benefit from interventions to reduce dietary iron absorption
2. ALL patients will be fully treated (i.e. undergoing phlebotomy to maintain iron stores within the normal range, following on from the removal of primary iron burden at diagnosis), in order to reduce variability in the data as iron absorption varies between fully treated and untreated/newly diagnosed patients
3. Patients will be adults (aged 18 or over), as type one hereditary haemochromatosis presents in adulthood

Exclusion Criteria

1. Patients with allergy to any foods or medicines will be excluded from participating for their own safety
2. Patients with gastrointestinal diseases which alter gut motility, gut permeability or gastric pH (ulcerative colitis, Crohn's disease, coeliac disease,
gastric ulceration) will also be excluded from participating as these disorders affect gastrointestinal function and, thus, may result in altered iron absorption and confound the results of the study

Study & Design

• Study Type: Interventional
• Study Design: Not specified