Study of Healthy Cohort for Early Detection of Cancer
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 10,000
- 试验地点
- 1
- 主要终点
- Development of malignancy
研究概览
简要总结
Cancer produces a significant burden on society with a majority diagnosed at late stages when the chance of cure is low. Early diagnosis improves patient outcomes. Data consisting of lifestyle factors, medications, physical activity, years before conventional cancer diagnosis is also worthwhile for to determine early detection. This is only achievable with longitudinal tracking of a large number of healthy individuals and identifying those who do develop cancer over time.
详细描述
To conduct a longitudinal cohort study of patients who do not have a malignancy at the time of enrollment and are followed over a 20 year period to see if patients develop a malignancy and associate clinical and lifestyle factors as well as collection of blood. All adults 18 years of age and older undergoing upper or lower endoscopy for routine medical care will be eligible for this study.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All adults 18 years of age of older undergoing upper or lower endoscopy for routine medical care.
排除标准
- •Persons with current malignancy
- •Persons with history of malignancy and treatment within last 5 years of enrollment, excluding non-melanoma skin cancer or cervical in-situ.
- •Persons who are unable or unwilling to provide repeat blood samples and complete follow-up questionnaires
- •Persons who lack the capacity to provide consent
- •Persons who do not speak English
- •Persons who are visually or hearing impaired.
结局指标
主要结局
Development of malignancy
时间窗: Up to 20 years
Assessment of participants for the development of malignancy during a 20-year follow-up period.
次要结局
- Development of biomarkers(Up to 20 years)