NL-OMON56570尚未招募不适用
COBRA re-KAI study: COVID-19 vaccination in patients with reduced B-cell and T-cell immunity: response after re-vaccination of a kaleidoscopic group of hematological patients: what*s the impact? - COBRA-RE-KAI
Amsterdam UMC0 个研究点目标入组 250 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 250
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 64（—）
入选标准
- •Age >=18 years
- •Patient groups:
- •Patients who received:
- •1. B cell depleting immunochemotherapy (n=50), at least 8 months after last
- •B-cel depleting therapy before first vaccination.6
- •2. B cell depleting CAR T cell therapy (n=50); 3 months after treatment.6
- •3. Patients who received autologous HCT (myeloablative chemotherapy: high dose
- •melphalan (HDM)) (n=50); 3 months after treatment before first vaccination 6.
- •4. Patients who received autologous HCT (myeloablative chemotherapy:
- •BCNU-etoposide-Ara-C-Melphalan (BEAM) or BCNU-thiotepa) (n=50); at least 3
- •months after transplantation with a maximum of 6 months before first
- •vaccination. 6
- •Group 5: Patients who received allogeneic HCT (various indications) (n=50) 3
- •months after transplantation.
排除标准
- •- Unwilling or unable to give informed consent
- •- Known allergy to one of the components of the vaccine
- •- Patients with a life expectancy of < 12 months
研究者
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