Direct Oral Anticoagulants and Management of Blleding Following Dental Extractions. A Prospective Cohort Study.
- Conditions
- Post Operative Hemorrhage
- Registration Number
- NCT06365242
- Lead Sponsor
- University of Pisa
- Brief Summary
Evaluation of DOACs treatment on post-extraction bleeding
- Detailed Description
Consecutive patients requiring at least one dental extraction were enrolled. DOACs regimen was either maintained or suspended. Patients were classified in subgroups depending on the number of teeth extracted per procedure (≤ 3 or \> 3), the need for flap raising and the performance of osteotomy. Bleeding was recorded intraoperatively, perioperatively at 20, 40, 60 and 80 minutes after the procedure, and in the first seven days post-operatively.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 49
- age >18 years
- patients under pharmacological treatment with DOACs
- patients requiring at least one dental extraction
- patients willing to take part in the study and to sign informed consent
- patients below 18 years of age
- patients treated with antiplatelet therapy or vitamin K antagonists
- patients presenting with an International Normalized Ratio (INR) >3.0
- patients suffering from congenital or acquired coagulopathies (e.g. haemophilia, coagulation factors deficiency, von Willebrand disease, thrombocytopenia, cirrhosis)
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Peri-operative hemorrhage 20 minutes to 80 minutes Evaluation of early post-operative hemorrhage classified as absent, mild, oozing, moderate, and severe.
Post-operative bleeding day 1 to 7 post-operatively Evaluation of post-operative bleeding classified as absent, mild, oozing, moderate, and severe.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
U.O. Odontostomatologia e Chirurgia del Cavo Orale
🇮🇹Pisa, Italy