A Clinical And Radiographical Comparsion Of Healing In The Extraction Socket Of The Mandibular First Molar With And Without The Use Of Platelet Rich Fibrin (PRF)-A Prospective Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- To evaluate the Bucco-Lingual of the alveolar ridge at baseline and three-month
研究概览
简要总结
Tooth extraction is a standard dental procedure used to manage various dental conditions. (Buchwald) The healing process after extraction is a complex series of bone cell migrations and maturation, leading to selective bone resorption and formation. This process reduces a dimensional alveolar ridge in horizontal and vertical directions. Replacing missing teeth, especially with implants, becomes more challenging due to the loss of necessary bone volume for successful implant placement. This post-extraction bone loss often requires bone grafting procedures to restore function and aesthetics reliably. Our study aims to shed light on this complex process and potentially offer a solution to the associated challenges.
Various procedures prevent post-extraction bone loss and ensure predictable implant placements, including socket preservation with grafts (biomaterials) and immediate or early implant placements. While clinicians have a range of graft materials to choose from, some bone graft materials require longer healing time to achieve even a small amount of new bone incorporation into the graft site (Norton and Wilson, 2002).
Platelet-rich fibrin (PRF) is a material derived from autologous blood preparation and is known for its exceptional ability to promote bone healing and regeneration. It acts as a scaffold and filler material due to its 3-dimensional structure, attracting and enriching various types of cells to migrate and proliferate here and accommodate them for extended periods. It contains multiple growth factors that can affect the expression of osteogenic genes, promote the metastasis and differentiation of mesenchymal stem cells, inhibit the generation of osteoclasts, and promote angiogenesis to achieve bone regeneration. Our study aims to harness this potential of PRF, adding it into the extraction socket and evaluating soft and hard tissue healing.
研究设计
- 研究类型
- Interventional
- 分配方式
- Coin toss, Lottery, toss of dice, shuffling cards etc
- 盲法
- Participant and Outcome Assessor Blinded
入排标准
- 年龄范围
- 21.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •1 Age from
- •65 years 2 Only the first mandibular molar cannot be restored if the patient is unwilling to restore it. 3 Patients without any habits like smoking, tobacco chewers, or anything that can hinder the healing process. 4 Patients who are willing to give informed consent for the procedure. 5 Patients who are willing to agree to adhere to the study protocols. 6 Patient with platelet count more than 1.5×103/mm3.
排除标准
- •1 Medically compromised patient 2 Patients with poor oral hygiene and periodontally compromise 3 Patient who will undergo trans alveolar extraction.
- •4 Patient cannot adhere to the schedule or is unwilling to give written consent.
结局指标
主要结局
To evaluate the Bucco-Lingual of the alveolar ridge at baseline and three-month
时间窗: At base line and 12 weeks later buccolingual width of socket and bone height will be evaluated
2) Alevolar bone height at baseline and three months using radiograph.
时间窗: At base line and 12 weeks later buccolingual width of socket and bone height will be evaluated
次要结局
未报告次要终点
研究者
Yash Ajmera
Governemt dental college and hospital