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In vivo and non-invasive measurement of cytokine release in a model of acute and local skin inflammatio

Completed
Conditions
cytokines
inflammatory molecules
10014982
Registration Number
NL-OMON43271
Lead Sponsor
Radboud Universitair Medisch Centrum
Brief Summary

Not available

Detailed Description

Not available

Recruitment & Eligibility

Status
Completed
Sex
Not specified
Target Recruitment
10
Inclusion Criteria

Age between 18 and 65 years;
Must be willing to give a written informed consent;
Must have skin type I, II or III (Fitzpatrick scale).

Exclusion Criteria

Diagnosis of histamine hypersensitivity;
Predisposition to respond allergic (including diagnosis of allergy to silver or to other device-related material);
Presence of cardiac pacemakers or other implanted electric devices;
Pregnancy or lactation;
Atopic predisposition (i.e. history of allergic rhinitis or allergic conjunctivitis, atopic or contact dermatitis, hay fever, asthma);
Any (skin) disease, including possible lesions found during screening;
Skin type IV, V, VI (Fitzpatrick scale);
Use of immunosuppressive drugs (NSAIDs; biologicals; topical or systemic corticosteroids);
Use of antihistamines drugs;
Use of medication for hypertension with airway constricting activity (e.g. beta blockers);
Excessive sun exposure or tanning at the moment of screening.

Study & Design

Study Type
Observational non invasive
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
<p>The main study endpoints are the levels of cytokines at baseline and at<br /><br>different time points following local skin inflammation elicited by histamine<br /><br>iontophoresis. </p><br>
Secondary Outcome Measures
NameTimeMethod
<p>Not applicable.</p><br>
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