In vivo and non-invasive measurement of cytokine release in a model of acute and local skin inflammatio
- Conditions
- cytokinesinflammatory molecules10014982
- Registration Number
- NL-OMON43271
- Lead Sponsor
- Radboud Universitair Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 10
Age between 18 and 65 years;
Must be willing to give a written informed consent;
Must have skin type I, II or III (Fitzpatrick scale).
Diagnosis of histamine hypersensitivity;
Predisposition to respond allergic (including diagnosis of allergy to silver or to other device-related material);
Presence of cardiac pacemakers or other implanted electric devices;
Pregnancy or lactation;
Atopic predisposition (i.e. history of allergic rhinitis or allergic conjunctivitis, atopic or contact dermatitis, hay fever, asthma);
Any (skin) disease, including possible lesions found during screening;
Skin type IV, V, VI (Fitzpatrick scale);
Use of immunosuppressive drugs (NSAIDs; biologicals; topical or systemic corticosteroids);
Use of antihistamines drugs;
Use of medication for hypertension with airway constricting activity (e.g. beta blockers);
Excessive sun exposure or tanning at the moment of screening.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main study endpoints are the levels of cytokines at baseline and at<br /><br>different time points following local skin inflammation elicited by histamine<br /><br>iontophoresis. </p><br>
- Secondary Outcome Measures
Name Time Method <p>Not applicable.</p><br>