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Clinical Trials/NCT03356743
NCT03356743CompletedNot Applicable

Spectrum Analysis of Endobronchial Ultrasound Radiofrequency of Lung Tumors in Ex-vivo Human Lungs

University Health Network, Toronto2 sites in 1 country20 target enrollmentStarted: July 12, 2017Last updated:
Conditions
Interventions

Trial Snapshot

Phase
Not Applicable
Status
Completed
Enrollment
20
Locations
2
Primary Endpoint
To analyze the relationship of three spectral features of the radiofrequency of lung tumors in ex-vivo human lungs.

Study Overview

Brief Summary

This study will analyze spectral features of the radiofrequency of lung tumors in ex-vivo human lungs. The resected specimens will be evaluated using the spectrum analysis to determine the localization rate of the targets. Ultrasound measurement and images will be used for correlation of TS mode image findings with pathology by using HE and IHC slides of lung tumor and lymph node.

Study Design

Study Type
Interventional
Allocation
Non Randomized
Intervention Model
Single Group
Primary Purpose
Diagnostic
Masking
None

Eligibility Criteria

Ages
18 Years to — (Adult, Older Adult)
Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Any patients scheduled for lobectomy of anatomical segmental resection for malignant lung tumors.
  • 18 years of age or older

Exclusion Criteria

  • Any patients with inability to give informed consent.

Arms & Interventions

Ex-Vivo

Experimental

Intervention: Spectrum Analysis (Device)

Outcomes

Primary Outcomes

To analyze the relationship of three spectral features of the radiofrequency of lung tumors in ex-vivo human lungs.

Time Frame: Within an hour after resection.

From obtained ultrasound images, a linear regression line is quantified, and three ultrasonic spectral parameters including Midband-fit, Intercept, and Slope are calculated.

Secondary Outcomes

  • To find the correlation of TS mode image findings with pathology by using lung tumor and lymph node samples.(Within an hour after resection)
  • To clarify the feasibility of using the conventional EBUS scope to visualize solitary pulmonary nodules in an ex-vivo human lung.(Within an hour after resection)

Investigators

Sponsor Class
Other
Responsible Party
Sponsor

Study Sites (2)

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